Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells compared to α-Amanitin [1].
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Description | RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells compared to α-Amanitin [1]. |
In vitro | RNA polymerase II-IN-1 (compound 19iv) demonstrates cytotoxic effects on CHO, HEK293, and HeLa cell lines, exhibiting IC50 values of 0.19 μM, 0.20 μM, and 3.32 μM, respectively. Compared to α-Amanitin, it shows reduced toxicity in HepG2 cells, with an IC50 of 5.6 μM, which is 2.7-fold lower [1]. |
Molecular Weight | 887.96 |
Formula | C38H53N11O12S |
CAS No. | 2891451-07-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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RNA polymerase II-IN-1 2891451-07-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit