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A2ti-1

🥰Excellent
Catalog No. T36432Cas No. 570390-00-0

A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK). A2ti-1 can be used to study human papillomavirus type 16 (HPV16) infection.

A2ti-1

A2ti-1

🥰Excellent
Purity: 99.86%
Catalog No. T36432Cas No. 570390-00-0
A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK). A2ti-1 can be used to study human papillomavirus type 16 (HPV16) infection.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$90In StockIn Stock
5 mg$222In StockIn Stock
10 mg$347In StockIn Stock
25 mg$689In StockIn Stock
50 mg$1,090In StockIn Stock
100 mg$1,490In StockIn Stock
500 mg$2,980-In Stock
1 mL x 10 mM (in DMSO)$318In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.86%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK). A2ti-1 can be used to study human papillomavirus type 16 (HPV16) infection.
Targets&IC50
A2t:24 μM
In vitro
The high-affinity A2ti-1 (100 μM; 72 h) reduces HPV16 PsV infection in HeLa cells in a dose-dependent manner[2].
Chemical Properties
Molecular Weight382.48
FormulaC20H22N4O2S
Cas No.570390-00-0
SmilesCCc1ccccc1-n1c(COc2ccccc2C)nnc1SCC(N)=O
Relative Density.1.26 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (209.16 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.63 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6145 mL13.0726 mL26.1452 mL130.7258 mL
5 mM0.5229 mL2.6145 mL5.2290 mL26.1452 mL
10 mM0.2615 mL1.3073 mL2.6145 mL13.0726 mL
20 mM0.1307 mL0.6536 mL1.3073 mL6.5363 mL
50 mM0.0523 mL0.2615 mL0.5229 mL2.6145 mL
100 mM0.0261 mL0.1307 mL0.2615 mL1.3073 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

VirusProteaseVirus ProteaseHPVA2ti-1A-2ti-1A2ti1A2ti 1
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