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2-Methoxyidazoxan monohydrochloride
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Catalog No. T23283Cas No. 109544-45-8
Alias RX 821002 hydrochloride
L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity for the alpha 2D adrenergic receptor (pKd9.7) in guinea pigs than for the alpha 2A adrenergic receptor (pKd8.2) in rabbits.
2-Methoxyidazoxan monohydrochloride
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Purity: 98.99%
Catalog No. T23283Alias RX 821002 hydrochlorideCas No. 109544-45-8
L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity for the alpha 2D adrenergic receptor (pKd9.7) in guinea pigs than for the alpha 2A adrenergic receptor (pKd8.2) in rabbits.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $38 | In Stock | In Stock | |
| 25 mg | $73 | In Stock | In Stock | |
| 50 mg | $133 | In Stock | In Stock | |
| 100 mg | $213 | In Stock | In Stock | |
| 200 mg | $316 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.99%
Appearance:Solid
Color:White
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Product Introduction
2-Methoxyidazoxan monohydrochloride AI Summary
2-Methoxyidazoxan monohydrochloride exhibits diverse bioactivity across multiple assays. It demonstrates significant antiplasmodial activity, particularly against the Plasmodium falciparum W2 strain with an IC50 value of 7943.28 nM as determined by the SYBR green assay. Apart from its antimalarial properties, 2-Methoxyidazoxan monohydrochloride acts as a differential inhibitor of proliferation in various Plasmodium falciparum strains and shows inhibitory activities in assays related to leukemia, Bloom's syndrome helicase, lipid storage modulation, B-cell receptor signaling, delayed death in malarial parasites, hepatitis C virus, TDP-43, and human apurinic/apyrimidinic endonuclease 1, with the most potent inhibition observed in the latter. Additionally, 2-Methoxyidazoxan monohydrochloride binds with high affinity to the alpha2-adrenergic receptor in the prefrontal cortex of the human brain, indicated by a Ki value of 1.905 nM, suggesting potent antagonistic activity and potential use in modulating adrenergic signaling pathways in the brain..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity for the alpha 2D adrenergic receptor (pKd9.7) in guinea pigs than for the alpha 2A adrenergic receptor (pKd8.2) in rabbits. |
| Synonyms | RX 821002 hydrochloride |
| Molecular Weight | 270.72 |
| Formula | C12H14N2O3·HCl |
| Cas No. | 109544-45-8 |
| Smiles | Cl.COC1(COc2ccccc2O1)C1=NCCN1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: Soluble DMSO: 4 mg/mL (14.78 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
α2-adrenoceptorventralselectiveRX-821002 HydrochlorideRX821002 HydrochlorideRX-821002RX821002RX 821002 HydrochlorideRX 821002neonatallesionInhibitorinhibithippocampalbiphasicBeta ReceptoradrenoceptorsAdrenergicReceptorAdrenergic Receptor2-Methoxyidazoxan monohydrochloride2Methoxyidazoxan monohydrochloride2-Methoxyidazoxan2 Methoxyidazoxan monohydrochloride
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