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Cytoskeletal SignalingMicrotubule Associated
Microtubule-associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. A large variety of MAPs have been identified in many different cell types, and they have been found to carry out a wide range of functions. These include both stabilizing and destabilizing microtubules, guiding microtubules towards specific cellular locations, cross-linking microtubules and mediating the interactions of microtubules with other proteins in the cell.
Maytansinol
Ansamitocin P-0
T1601657103-68-1
Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.
- $30
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Paclitaxel
Cited
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
- $34
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CitedIxabepilone Cited
Ixempra, BMS 247550-1, BMS 247550, Azaepothilone B
T6864219989-84-1
Ixabepilone (Azaepothilone B) is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
- $52
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CitedColcemid Cited
NSC-3096, Kolchicin, Demecolcine, C-12669, C12669, C 12669
T19720477-30-5
Colcemid (NSC-3096) is a microtubule polymerization inhibitor, with the main target being Tubulin and an IC50 of 2.4 μM. Colcemid can induce apoptosis and can be used in the research of tumors and embryo cloning.
- $33
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CitedNocodazole Cited
R17934, Oncodazole
T280231430-18-9
Nocodazole (Oncodazole) is a reversible inhibitor of microtubule polymerization and an inhibitor of Bcr-Abl. Nocodazole has antitumor activity, blocks the cell cycle and induces apoptosis.
- $31
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CitedDocetaxel Cited
RP-56976, NSC 628503
T1034114977-28-5
Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 μM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
- $30
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CitedAnandamide
(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide
T1404694421-68-8
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system.
- $30
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Sovilnesib
AMG650
T399942410796-79-9
Sovilnesib is a kinesin-like protein KIF18A inhibitor. Sovilnesib can be used for the cancer research.
- $97
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Eribulin mesylate
ER-086526 mesylate, E7389 mesylate, B1939 mesylate
T13687441045-17-6
Eribulin mesylate (E7389 mesylate) (E7389 mesylate) inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used in the treatment of metastatic breast cancer.
- $288
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VCMMAE
mc-vc-PAB-MMAE
T4232646502-53-6
VCMMAE (mc-vc-PAB-MMAE) is a drug-linker conjugate for ADC with potent antitumor activity.
- $30
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Donanemab
LY3002813
T771621931944-80-7
Donanemab (LY3002813) is a humanized IgG1 monoclonal antibody that targets a pyroglutamate amyloid beta (Aβ) epitope at the N-terminus, showing potential for early Alzheimer's disease research [1] [2].
- $228
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ER-086526, E7389, B1939
T13688253128-41-5
Eribulin (B1939) is a nonpaclitaxel microtubule kinetic inhibitor with anticancer activity that inhibits polymerization of microtubule protein subunits by preventing lengthening and shortening of microtubules during cell division.Eribulin is used in the study of metastatic breast cancer and solid tumors.
- $98
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Monomethyl auristatin E Cited
Vedotin, MMAE
T6897474645-27-7
Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.
- $41
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CitedLY3372689
Formulaic Ia
T616612241514-56-5In house
LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor targeting tau protein-based disorders, including Alzheimer's disease.
- $100
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Vinblastine sulfate Cited
Vincaleukoblastine sulfate salt, NSC49842
T1668143-67-9
Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).
- $50
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CitedCRT-0105950
CRT0105950, CRT 0105950
T239171661845-86-8
CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.
- $59
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C004019
T678342417159-57-8In house
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
- $263
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Sulforaphene
TL0016592-95-0
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signa
- $30
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Tirbanibulin Cited
KX2-391, KX-01
T6345897016-82-9
Tirbanibulin (KX2-391) is a highly selective Src kinase inhibitor that has demonstrated efficacy in pre-Clinicalal animal models of colon, pancreatic, prostate and breast cancer. It is a substrate-targeted kinase inhibitor. KX2-391, belongs to an emerging new family of targeted cancer treatments called protein kinase inhibitors.
- $30
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CitedFlubendazole
NSC 313680, Fluvermal, Flumoxane, Flumoxanal
T000931430-15-6
Flubendazole (Flumoxane) is available OTC in Europe that is an anthelmintic using to treat worm infection in humans.
- $33
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Fosbretabulin Disodium Cited
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, Combretastatin A4 Phosphate, Combretastatin A4 disodium phosphate, CA 4P, CA 4DP
T6272168555-66-6
Fosbretabulin Disodium (CA 4P), a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium(Combretastatin A4 disodium phosphate) inhibits the polymerization of tubulin (IC50: 2.4 μM), and also disrupts tumor vasculature.
- $32
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Cited2-Methoxyestradiol Cited
NSC-659853, 2-MeOE2, 2-ME2
T2220362-07-2
2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis.
- $37
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CitedMMAF
MonoMethyl auristatin F
T3256745017-94-1
MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.
- $40
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Leucomethylene blue mesylate Cited
TRx0237 mesylate, TRx0237 (LMTX) mesylate, Methylene blue leuco base mesylate salt, Leucomethylene Blue Dimesylate
T70031236208-20-0
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
- $33
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