PDGFRA Protein, Mouse, Recombinant (His)

Name: PDGFRA Protein, Mouse, Recombinant (His)
Brand: TargetMol
SKU: TMPY-05787
Rating: 4.5 (1 reviews)

(Synonyms: platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide, Pdgfr-2, CD140a, AI115593) Copy Product Info

Synonyms: platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide, Pdgfr-2, CD140a, AI115593

Catalog No. TMPY-05787 Copy Product Info

PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession number is P26618-2.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$357	7-10 days	7-10 days
100 µg	$622	7-10 days	7-10 days
200 µg	$1,070	7-10 days	7-10 days
500 µg	$2,250	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized Mouse PDGFRA His at 2 μg/ml (100 μl/well) can bind Cynomolgus PDGF-B mFc, the EC50 of Cynomolgus PDGF-B mFc is 150-700 ng/mL.
Description	PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession number is P26618-2.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P26618-2
Construction	A DNA sequence encoding the Mouse PDGFRA (NP_001334647.1) (Met1-Ala528) was expressed with a polyhistide tag at the C-terminus. Predicted N terminal: Leu 25
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	platelet-derived growth factor receptor, α polypeptide, platelet-derived growth factor receptor, alpha polypeptide, Pdgfr-2, CD140a, AI115593
Research Background	PDGFRA, also known as CD140a, together with the structurally homolog protein PDGFRB (CD140b), are cell surface receptors for members of the platelet-derived growth factor family. They are members of the class III subfamily of receptor tyrosine kinase (RTKs) with the similar structure characteristics of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGFRA is expressed in oligodendrocyte progenitor cells and mesothelial cell, and binds all three ligand isoforms PDGF-AA, PDGF-BB and PDGF-AB with high affinity, whereas PDGFRB dose not bind PDGF-AA. PDGFRA plays an essential role in regulating proliferation, chemotaxis and migration of mesangial cells. Recent studies have indicated that PDGFRA acts as a critical mediator of signaling in testis organogenesis and Leydig cell differentiation, and in addition, particularly important for kidney development. Additionally, PDGFRA is involved in tumor angiogenesis and maintenance of the tumor microenvironment and has been implicated in development and metastasis of Hepatocellular carcinoma (HCC). PDGFRA may represent a potential therapeutic target in thymic tumours. PDGFRA gene amplification rather than gene mutation may be the underlying genetic mechanism driving PDGFRA overexpression in a portion of gliomas.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

57.87 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.