Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Potent Chk2 inhibitor (IC50 = 3 nM). Shows <63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 35 days | $ 983.00 |
Description | Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. |
Targets&IC50 | Chk1:245 nM (IC50), Chk2:1.16 nM (Ki), Chk2:3 nM (IC50) |
Synonyms | CCT 241533 dihydrochloride |
Molecular Weight | 515.41 |
Formula | C23H29Cl2FN4O4 |
CAS No. | 1962925-28-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
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CCT241533 dihydrochloride 1962925-28-5 CCT241533 Dihydrochloride CCT-241533 Dihydrochloride CCT-241533 dihydrochloride CCT-241533 CCT 241533 Dihydrochloride CCT 241533 CCT 241533 dihydrochloride CCT241533 inhibitor inhibit