Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 163.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 578.00 | |
50 mg | In stock | $ 913.00 | |
100 mg | In stock | $ 1,370.00 |
Description | NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. |
Targets&IC50 | β-catenin-β-TrCP:0.6 nM(Kd), β-catenin-β-TrCP:62 nM(EC50) |
In vitro |
RX-103094 demonstrates high potency against the pSer33/Ser37 β-catenin peptide with an EC50 of 457 nM. At 250 nM, NRX-103094 enhances the ubiquitylation of the pSer33/S37A β-catenin peptide to levels surpassing those of the wild-type pSer33/pSer37.[1] NRX-103094 significantly enhances the binding affinity of the S33E/S37A phosphomimetic peptide for β-TrCP, reducing it from >5 μM in the absence of the compound to 22 nM in the presence of 40 μM NRX-103094. In the presence of 20 μM NRX-103094, we observe robust, time-dependent ubiquitylation of the S33E/S37A β-catenin peptide. Similarly, when 20 μM NRX-103094 is present, the full-length S33E/S37A β-catenin protein undergoes strong ubiquitylation, with ubiquitylation levels approaching those of the WT full-length β-catenin protein.[1] |
Synonyms | NRX103094, NRX 103094 |
Molecular Weight | 503.28 |
Formula | C20H11Cl2F3N2O4S |
CAS No. | 2763260-36-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (79.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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NRX-103094 2763260-36-0 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin NRX103094 NRX 103094 inhibitor inhibit