Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 226.00 | |
5 mg | In stock | $ 562.00 | |
10 mg | In stock | $ 883.00 | |
25 mg | In stock | $ 1,450.00 | |
50 mg | In stock | $ 1,980.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 645.00 |
Description | BI-4142 is an orally active, potent and selective HER2 inhibitor that inhibits cancer cell proliferation, suppresses her2-dependent cell lines and inhibits downstream signalling. |
Targets&IC50 | Ba/F3 EGFRWT:2400 nM, Ba/F3 HER2YVMA:18 nM, HER2:5 nM, HEK HER2YVMA:10 nM, HEK EGFRWT:270 nM |
In vitro |
BI-4142 inhibits HER2-dependent cell lines and downstream signaling, with IC50 values of 10 nM, 18 nM, 270 nM, and 2400 nM against HEK HER2YVMA, Ba/F3 HER2YVMA, HEK EGFRWT, and Ba/F3 EGFRWT, respectively[1].BI-4142 (1 nM-5 μM, 72 h or 96 h) exhibits antiproliferative activity against tumor cells[1]. In the CaCo-2 assay, BI-4142 displays good permeability and no PgP-mediated efflux liability[1]. |
In vivo | BI-4142 administered at doses ranging from 0 to 100 mg/kg, orally twice daily for 40 days, significantly inhibits tumor growth and suppresses oncogenic signaling[1]. |
Molecular Weight | 521.57 |
Formula | C28H27N9O2 |
CAS No. | 2682003-36-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (153.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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BI-4142 2682003-36-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors HER inhibitor inhibit