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PSI-6130

Name: PSI-6130
Brand: TargetMol
SKU: T7607
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7607Cas No. 817204-33-4

Alias R 1656

PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.

PSI-6130

🥰Excellent

Purity: 99.79%

Catalog No. T7607Alias R 1656Cas No. 817204-33-4

PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$91	In Stock	In Stock
10 mg	$131	In Stock	In Stock
25 mg	$235	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$507	In Stock	In Stock
200 mg	$687	-	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.
Targets&IC50	HCV:0.6 μM
In vitro	PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC50 of 0.13 μM and Ki of 0.023 μM. PSI-6130 is metabolized to two pharmacologically active species in primary human hepatocytes[1].
Synonyms	R 1656

Chemical Properties

Molecular Weight	259.23
Formula	C₁₀H₁₄FN₃O₄
Cas No.	817204-33-4
Smiles	C[C@@]1(F)[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=N)[nH]c1=O
Relative Density.	1.67 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (192.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8576 mL	19.2879 mL	38.5758 mL	192.8789 mL
5 mM	0.7715 mL	3.8576 mL	7.7152 mL	38.5758 mL
10 mM	0.3858 mL	1.9288 mL	3.8576 mL	19.2879 mL
20 mM	0.1929 mL	0.9644 mL	1.9288 mL	9.6439 mL
50 mM	0.0772 mL	0.3858 mL	0.7715 mL	3.8576 mL
100 mM	0.0386 mL	0.1929 mL	0.3858 mL	1.9288 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc