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Lysophosphatidylcholine 18:2

Name: Lysophosphatidylcholine 18:2
Brand: TargetMol
SKU: T36791
Rating: 4.5 (1 reviews)

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Catalog No. T36791Cas No. 22252-07-9

Alias PC(18:2/0:0), 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC, 18:2/0:0-PC, 18:2 lyso-PC, 18:2 LysoPC

Lysophosphatidylcholine 18:2 is a mouse metabolite functionally related to linoleic acid.18:2 LysoPC is a major component of oxidized low-density lipoproteins (LDLs), and low plasma levels of LPC 18:2 have been associated with metabolic disorders such as impaired glucose tolerance, insulin resistance, type 2 diabetes, and coronary artery disease.1-Linoleoyl 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC is also a substrate for the generation of lysophosphatidic acid (LPA) from Autotaxin (LysoPLD), which plays an important role in cell motility.

Lysophosphatidylcholine 18:2

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Catalog No. T36791Alias PC(18:2/0:0), 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC, 18:2/0:0-PC, 18:2 lyso-PC, 18:2 LysoPCCas No. 22252-07-9

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$246	35 days	35 days
1 mg	$343	35 days	35 days
5 mg	$857	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Lysophosphatidylcholine 18:2 is a mouse metabolite functionally related to linoleic acid.18:2 LysoPC is a major component of oxidized low-density lipoproteins (LDLs), and low plasma levels of LPC 18:2 have been associated with metabolic disorders such as impaired glucose tolerance, insulin resistance, type 2 diabetes, and coronary artery disease.1-Linoleoyl 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC is also a substrate for the generation of lysophosphatidic acid (LPA) from Autotaxin (LysoPLD), which plays an important role in cell motility.
In vitro	Lysophosphatidylcholine 18:2 is a major glycerophospholipid in human plasma and has been implicated in inflammation, insulin resistance, obesity, and type 2 diabetes.[1]
Synonyms	PC(18:2/0:0), 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC, 18:2/0:0-PC, 18:2 lyso-PC, 18:2 LysoPC

Chemical Properties

Molecular Weight	519.65
Formula	C₂₆H₅₀NO₇P
Cas No.	22252-07-9
Smiles	CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)COP([O-])(=O)OCC[N+](C)(C)C

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 1 mg/mL (1.92 mM), Sonication is recommended.

Ethanol: 80 mg/mL (153.95 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.9244 mL	9.6219 mL	19.2437 mL	96.2186 mL

Ethanol

	1mg	5mg	10mg	50mg
5 mM	0.3849 mL	1.9244 mL	3.8487 mL	19.2437 mL
10 mM	0.1924 mL	0.9622 mL	1.9244 mL	9.6219 mL
20 mM	0.0962 mL	0.4811 mL	0.9622 mL	4.8109 mL
50 mM	0.0385 mL	0.1924 mL	0.3849 mL	1.9244 mL
100 mM	0.0192 mL	0.0962 mL	0.1924 mL	0.9622 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc