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Almonertinib hydrochloride

Name: Almonertinib hydrochloride
Brand: TargetMol
SKU: T5675
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5675Cas No. 2134096-03-8

Alias HS-10296 hydrochloride

Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

Almonertinib hydrochloride

🥰Excellent

Purity: 98.12%

Catalog No. T5675Alias HS-10296 hydrochlorideCas No. 2134096-03-8

Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$195	In Stock
10 mg	$328	In Stock
25 mg	$565	In Stock
50 mg	$793	In Stock
100 mg	$1,080	In Stock
500 mg	$2,190	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.12%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
Targets&IC50	EGFR (L858R/T790M):0.29 mM (IC50), EGFR (del19/T790M):0.214 nM (IC50), EGFR (T790M):0.37 nM (IC50)
In vitro	HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1].
Synonyms	HS-10296 hydrochloride

Chemical Properties

Molecular Weight	562.1
Formula	C₃₀H₃₆ClN₇O₂
Cas No.	2134096-03-8
Smiles	Cl.COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C2CC2)c2ccccc12
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (148.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7790 mL	8.8952 mL	17.7904 mL	88.9521 mL
5 mM	0.3558 mL	1.7790 mL	3.5581 mL	17.7904 mL
10 mM	0.1779 mL	0.8895 mL	1.7790 mL	8.8952 mL
20 mM	0.0890 mL	0.4448 mL	0.8895 mL	4.4476 mL
50 mM	0.0356 mL	0.1779 mL	0.3558 mL	1.7790 mL
100 mM	0.0178 mL	0.0890 mL	0.1779 mL	0.8895 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc