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IQM-266

😃Good
Catalog No. T210509Cas No. 1956337-58-8
Alias IQM266, IQM 266

IQM-266 is a DREAM ligand (KD = 4.63 μM) and KV4 current modulator. IQM-266 inhibits KV4.3/DREAM currents in a concentration-, voltage-, and time-dependent manner, increases transmembrane charge, and modulates IA currents in rat DRG neurons, making it a potential therapeutic candidate for neurological disorders.

IQM-266

IQM-266

😃Good
Purity: 99.86%
Catalog No. T210509Alias IQM266, IQM 266Cas No. 1956337-58-8
IQM-266 is a DREAM ligand (KD = 4.63 μM) and KV4 current modulator. IQM-266 inhibits KV4.3/DREAM currents in a concentration-, voltage-, and time-dependent manner, increases transmembrane charge, and modulates IA currents in rat DRG neurons, making it a potential therapeutic candidate for neurological disorders.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$195-In Stock
5 mg$483-In Stock
10 mg$691-In Stock
25 mg$1,080-In Stock
50 mg$1,490-In Stock
100 mg$1,960-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.86%
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Product Introduction

Bioactivity
Description
IQM-266 is a DREAM ligand (KD = 4.63 μM) and KV4 current modulator. IQM-266 inhibits KV4.3/DREAM currents in a concentration-, voltage-, and time-dependent manner, increases transmembrane charge, and modulates IA currents in rat DRG neurons, making it a potential therapeutic candidate for neurological disorders.
In vitro
IQM-266 (3-10 μM) dose-dependently reduced the peak amplitude of IA in rat dorsal root ganglion (DRG) neurons [1]. When depolarizing pulse stimulation was applied, IQM-266 (3 μM) increased transmembrane charge transfer in CHO cells while decreasing the peak amplitude of IA current and slowing its inactivation process [1].
SynonymsIQM266, IQM 266
Chemical Properties
Molecular Weight397.42
FormulaC25H19NO4
Cas No.1956337-58-8
SmilesO=C(O)C1=CC=2C=CC=CC2C=C1NC(=O)CC=3C=CC=C(OC=4C=CC=CC4)C3
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (201.30 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5162 mL12.5811 mL25.1623 mL125.8115 mL
5 mM0.5032 mL2.5162 mL5.0325 mL25.1623 mL
10 mM0.2516 mL1.2581 mL2.5162 mL12.5811 mL
20 mM0.1258 mL0.6291 mL1.2581 mL6.2906 mL
50 mM0.0503 mL0.2516 mL0.5032 mL2.5162 mL
100 mM0.0252 mL0.1258 mL0.2516 mL1.2581 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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