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Anti-RanBP3 Antibody (4E390)

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Catalog No. TMAB-12074

Anti-RanBP3 Antibody (4E390) is a Rabbit antibody targeting RanBP3. Anti-RanBP3 Antibody (4E390) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, IP.

Anti-RanBP3 Antibody (4E390)

Anti-RanBP3 Antibody (4E390)

😃Good
Catalog No. TMAB-12074
Anti-RanBP3 Antibody (4E390) is a Rabbit antibody targeting RanBP3. Anti-RanBP3 Antibody (4E390) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, IP.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1497-10 days7-10 days
50 μL$2627-10 days7-10 days
100 μL$4717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-RanBP3 Antibody (4E390) is a Rabbit antibody targeting RanBP3. Anti-RanBP3 Antibody (4E390) can be used in FCM, ICC/IF, IF, IHC-Fr, IHC-P, IP.
Ig Type
IgG
Clone
4E390
Reactivity
Human,Mouse,Rat
Application
FCM
ICC/IF
IF
IHC-Fr
IHC-P
IP
Recommended Dose
FCM=1:50-100; ICC/IF=1:50-200; IF=1:100-500; IHC-Fr=1:100-500; IHC-P=1:100-500; IP=1:20-50
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus.
Tissue SpecificityWidely expressed with high levels in testis and heart.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundActs as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner.
Antigen Details
Immunogen
A synthesized peptide: human RanBP3
Antigen Species
Human
Gene Name
RANBP3
Gene ID
8498
Protein Name
Ran-binding protein 3
Uniprot ID
Q9H6Z4
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Chemical Properties
Molecular WeightTheoretical: 60 kDa. Actual: 70, 90 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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