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Loxoprofen sodium

Name: Loxoprofen sodium
Brand: TargetMol
SKU: T0463L
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T0463LCas No. 80382-23-6

Alias Loxoprofen, CS-600, CS600, CS 600

Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen sodium has anti-inflammatory and antitumor activity and can be used to treat atherosclerosis.

Loxoprofen sodium

🥰Excellent

Purity: 99.88%

Catalog No. T0463LAlias Loxoprofen, CS-600, CS600, CS 600Cas No. 80382-23-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$37	In Stock	In Stock
50 mg	$55	In Stock	In Stock
100 mg	$80	In Stock	In Stock
500 mg	$200	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Loxoprofen sodium (CS-600) is an effective and oral sodium inhibitor of COX-1 and COX-2 with IC50 of 6.5 and 13.5 μM, respectively. Loxoprofen sodium works by reducing the synthesis of prostaglandins from arachidonic acid. Loxoprofen sodium has anti-inflammatory and antitumor activity and can be used to treat atherosclerosis.
Targets&IC50	COX-2:13.5 μM, COX-1:6.5 μM
In vitro	'Loxoprofen sodium, an anti-inflammatory prodrug, is a nonselective COX inhibitor with IC50s of 6.5 and 13.5μM for COX-1 and COX-2 in human whole blood assays, respectively.[1] Loxoprofen sodium is a non-selective cyclooxygenase inhibitor that is widely used for the research of pain and inflammation caused by chronic and transitory conditions. In addition, LOX sodium can also be converted into an inactive hydroxylated metabolite (OH-LOXs) by cytochrome P450 (CYP).[2]'
In vivo	"Loxoprofen reduces acetic acid-induced writhing in mice and carrageenan-induced paw edema and LPS-induced fever in rats (ED30s = 20.1, 0.7, and 2.79 mg/kg, respectively).[3] Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) reduces atherosclerosis in mice by reducing inflammation[4]. Loxoprofen sodium (60 μg/mL; p.o.; 24 days) suppresses mouse tumor growth by inhibiting VEGF[5]."
Synonyms	Loxoprofen, CS-600, CS600, CS 600

Chemical Properties

Molecular Weight	268.2834
Formula	C₁₅H₁₇NaO₃
Cas No.	80382-23-6
Smiles	[Na+].CC(C([O-])=O)C1=CC=C(CC2CCCC2=O)C=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13 mg/mL (48.46 mM), Sonication is recommended.

H2O: 90 mg/mL (335.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.7274 mL	18.6370 mL	37.2740 mL	186.3701 mL
5 mM	0.7455 mL	3.7274 mL	7.4548 mL	37.2740 mL
10 mM	0.3727 mL	1.8637 mL	3.7274 mL	18.6370 mL
20 mM	0.1864 mL	0.9319 mL	1.8637 mL	9.3185 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0745 mL	0.3727 mL	0.7455 mL	3.7274 mL
100 mM	0.0373 mL	0.1864 mL	0.3727 mL	1.8637 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc