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Oleoyl-L-carnitine chloride (Alias: L-Octadecanoylcarnitine, L-Carnitine oleoyl ester, CAR 18:1, C18:1 Car...)

Catalog No. T83872 Copy Product Info
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Oleoyl-L-carnitine, a long-chain acylcarnitine, acts as a selective inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM) while demonstrating significantly lesser affinity for GlyT1 (IC50 = >10,000 nM). Elevated plasma levels of this compound have been observed in patients suffering from chronic kidney disease or end-stage renal disease undergoing initial hemodialysis, correlating with an increased risk of cardiovascular mortality.

Oleoyl-L-carnitine chloride

Copy Product Info
🥰Excellent
Catalog No. T83872
Alias L-Octadecanoylcarnitine, L-Carnitine oleoyl ester, CAR 18:1, C18:1 Carnitine

Oleoyl-L-carnitine, a long-chain acylcarnitine, acts as a selective inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM) while demonstrating significantly lesser affinity for GlyT1 (IC50 = >10,000 nM). Elevated plasma levels of this compound have been observed in patients suffering from chronic kidney disease or end-stage renal disease undergoing initial hemodialysis, correlating with an increased risk of cardiovascular mortality.

Oleoyl-L-carnitine chloride
Cas No. 31062-78-9
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$24335 days35 days
5 mg$59535 days35 days
10 mg$1,09035 days35 days
25 mg$2,08035 days35 days
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Oleoyl-L-carnitine, a long-chain acylcarnitine, acts as a selective inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM) while demonstrating significantly lesser affinity for GlyT1 (IC50 = >10,000 nM). Elevated plasma levels of this compound have been observed in patients suffering from chronic kidney disease or end-stage renal disease undergoing initial hemodialysis, correlating with an increased risk of cardiovascular mortality.
SynonymsL-Octadecanoylcarnitine, L-Carnitine oleoyl ester, CAR 18:1, C18:1 Carnitine
Chemical Properties
Molecular Weight462.11
FormulaC25H48NO4.Cl
Cas No.31062-78-9
SmilesOC(C[C@H](C[N+](C)(C)C)OC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[Cl-]
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 30 mg/mL (64.92 mM), Sonication is recommended.
DMSO: 30 mg/mL (64.92 mM), Sonication is recommended.
DMF: 30 mg/mL (64.92 mM), Sonication is recommended.
PBS pH 7.2: 1 mg/mL (2.16 mM), Sonication is recommended.
Solution Preparation Table
PBS pH 7.2/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.1640 mL10.8199 mL21.6399 mL108.1993 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.4328 mL2.1640 mL4.3280 mL21.6399 mL
10 mM0.2164 mL1.0820 mL2.1640 mL10.8199 mL
20 mM0.1082 mL0.5410 mL1.0820 mL5.4100 mL
50 mM0.0433 mL0.2164 mL0.4328 mL2.1640 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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