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RS 61443

Name: RS 61443
Brand: TargetMol
SKU: T0245
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: TM-MMF, RS61443, Mycophenolate mofetil) Copy Product Info

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Synonyms: TM-MMF, RS61443, Mycophenolate mofetil

Catalog No. T0245 Copy Product Info

Purity: 99.96%

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RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)

Cas No. 115007-34-6

Pack Size	Price	USA Stock	Global Stock
25 mg	$31	In Stock	In Stock
50 mg	$44	In Stock	In Stock
100 mg	$63	In Stock	In Stock
200 mg	$97	In Stock	In Stock
500 mg	$165	In Stock	In Stock
1 g	$257	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	RS 61443 (Mycophenolate mofetil) is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
In vitro	Mycophenolate mofetil (MMF) is a relatively new systemic immunosuppressive agent whose use is rapidly increasing within the field of dermatologic. Originally used in the 1970s for the treatment of psoriasis, MMF has demonstrated efficacy in multiple types of inflammatory skin diseases. Although the safety data within the dermatologic literature is sparse, MMF's extensive use within the field of organ transplantation has demonstrated a favorable safety profile. MMF's lack of hepatic or renal toxicity is a significant advantage over immunosuppressive medications currently used in dermatology and make MMF an attractive candidate for multidrug regimens.
Synonyms	TM-MMF, RS61443, Mycophenolate mofetil

Chemical Properties

Molecular Weight	433.5
Formula	C₂₃H₃₁NO₇
Cas No.	115007-34-6
Smiles	O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC
Relative Density.	1.222 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M NAOH: 127.5 mg/mL (294.12 mM), Sonication is recommended.

DMSO: 257.5 mg/mL (594 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (23.07 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

1M NAOH/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3068 mL	11.5340 mL	23.0681 mL	115.3403 mL
5 mM	0.4614 mL	2.3068 mL	4.6136 mL	23.0681 mL
10 mM	0.2307 mL	1.1534 mL	2.3068 mL	11.5340 mL
20 mM	0.1153 mL	0.5767 mL	1.1534 mL	5.7670 mL
50 mM	0.0461 mL	0.2307 mL	0.4614 mL	2.3068 mL
100 mM	0.0231 mL	0.1153 mL	0.2307 mL	1.1534 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc