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DPH

Name: DPH
Brand: TargetMol
SKU: T15164
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15164Cas No. 484049-04-9

DPH is a potent, cell-permeable activator of c-Abl, demonstrating significant enzymatic and cellular efficacy in stimulating c-Abl activation.

DPH

🥰Excellent

Purity: 99.65%

Catalog No. T15164Cas No. 484049-04-9

DPH is a potent, cell-permeable activator of c-Abl, demonstrating significant enzymatic and cellular efficacy in stimulating c-Abl activation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$591	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$77	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DPH is a potent, cell-permeable activator of c-Abl, demonstrating significant enzymatic and cellular efficacy in stimulating c-Abl activation.
In vitro	DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation. DPH binds to the myristoyl binding site. It also prevents the formation of the bent conformation of the αI helix through steric hindrance. Which is a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site [1].

Chemical Properties

Molecular Weight	336.32
Formula	C₁₈H₁₃FN₄O₂
Cas No.	484049-04-9
Smiles	Fc1ccc(cc1)-c1nn(cc1C1NC(=O)NC1=O)-c1ccccc1
Relative Density.	1.45 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (267.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9734 mL	14.8668 mL	29.7336 mL	148.6679 mL
5 mM	0.5947 mL	2.9734 mL	5.9467 mL	29.7336 mL
10 mM	0.2973 mL	1.4867 mL	2.9734 mL	14.8668 mL
20 mM	0.1487 mL	0.7433 mL	1.4867 mL	7.4334 mL
50 mM	0.0595 mL	0.2973 mL	0.5947 mL	2.9734 mL
100 mM	0.0297 mL	0.1487 mL	0.2973 mL	1.4867 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc