Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody
😃Good
Catalog No. TMAB-11104
Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK1/2/3 (Thr423). Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody
Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody
😃Good
Catalog No. TMAB-11104
Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK1/2/3 (Thr423). Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PAK1/2/3 (Thr423). Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Cell junction, focal adhesion. Note=Recruited to focal adhesions upon activation. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PAK1 around the phosphorylation site of Thr423 |
| Antigen Species | Human |
| Gene Name | PAK1 |
| Gene ID | |
| Protein Name | Serine/threonine-protein kinase PAK 1 |
| Uniprot ID | |
| Function | The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. Phosphorylates MYL9/MLC2. Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. |
| Molecular Weight | Theoretical: 60 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody | purchase Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody | Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody cost | order Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody | Anti-Phospho-PAK1/2/3 (Thr423) Polyclonal Antibody molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.