Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Exicorilant

Name: Exicorilant
Brand: TargetMol
SKU: T15264
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T15264Cas No. 1781244-77-6

Alias CORT 125281

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

Exicorilant

😃Good

Catalog No. T15264Alias CORT 125281Cas No. 1781244-77-6

Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$3,970	3-6 months	3-6 months
50 mg	$5,550	3-6 months	3-6 months
100 mg	$7,490	3-6 months	3-6 months

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Exicorilant is a selective and oral active glucocorticoid receptor (GR) antagonist (Ki: 7 nM) and it also has the potential to overcome adiposity, glucose intolerance, and dyslipidemia.
Targets&IC50	GR:（ki）7 nM
In vitro	Exicorilant reverses corticosterone-mediated GR activity in murine brown adipocytes [1].
In vivo	Exicorilant decreases fat mass, body weight, and plasma lipids in HFD-fed mice. Exicorilant (6, 20, or 60 mg/kg/d, for 3 weeks in mice) at different dosages reduce fat mass, body weight, plasma TG, cholesterol, and FFA in a dose-dependent manner. But it has no effect on lean mass [2].
Synonyms	CORT 125281

Chemical Properties

Molecular Weight	589.56
Formula	C₂₆H₂₃F₄N₇O₃S
Cas No.	1781244-77-6
Smiles	C(=O)([C@@]12[C@](CC3=C(C1)C=NN3C4=CC=C(F)C=C4)(CCN(S(=O)(=O)C5=NN(C)N=C5)C2)[H])C6=CC(C(F)(F)F)=CC=N6
Relative Density.	1.59 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (424.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6962 mL	8.4809 mL	16.9618 mL	84.8090 mL
5 mM	0.3392 mL	1.6962 mL	3.3924 mL	16.9618 mL
10 mM	0.1696 mL	0.8481 mL	1.6962 mL	8.4809 mL
20 mM	0.0848 mL	0.4240 mL	0.8481 mL	4.2405 mL
50 mM	0.0339 mL	0.1696 mL	0.3392 mL	1.6962 mL
100 mM	0.0170 mL	0.0848 mL	0.1696 mL	0.8481 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

GR ExicorilantCORT-125281CORT125281