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CZC-25146 hydrochloride

Name: CZC-25146 hydrochloride
Brand: TargetMol
SKU: T5139
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5139Cas No. 1330003-04-7

CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.

CZC-25146 hydrochloride

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Purity: 98.76%

Catalog No. T5139Cas No. 1330003-04-7

CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$67	In Stock
10 mg	$119	In Stock
25 mg	$197	In Stock
50 mg	$295	In Stock
100 mg	$430	In Stock
200 mg	$597	In Stock

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.76%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
Targets&IC50	LRRK2 (G2019S):6.87 nM, LRRK2 (WT):4.76 nM
In vitro	CZC-25146 inhibited only five kinases(PLK4, GAK, TNK1, CAMKK2, and PIP4K2C) with high potency. CZC-25146 neither caused cytotoxicity in human cortical neurons at concentrations below 5 μM over a seven-day treatment in culture nor did it block neuronal development in vitro.
In vivo	CZC-25146 possesses favorable pharmacokinetic properties, such as a volume of distribution of 5.4 L/kg and clearance of 2.3 L/hr/kg that render it suitable for in-vivo studies.

Chemical Properties

Molecular Weight	525
Formula	C₂₂H₂₆ClFN₆O₄S
Cas No.	1330003-04-7
Smiles	Cl.COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (104.76 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9048 mL	9.5238 mL	19.0476 mL	95.2381 mL
5 mM	0.3810 mL	1.9048 mL	3.8095 mL	19.0476 mL
10 mM	0.1905 mL	0.9524 mL	1.9048 mL	9.5238 mL
20 mM	0.0952 mL	0.4762 mL	0.9524 mL	4.7619 mL
50 mM	0.0381 mL	0.1905 mL	0.3810 mL	1.9048 mL
100 mM	0.0190 mL	0.0952 mL	0.1905 mL	0.9524 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc