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Anti-FOLR1 Antibody (2B73)
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Catalog No. TMAY-01793
Alias FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP
Anti-FOLR1 Antibody (2B73) is a Mouse antibody targeting FOLR1. Anti-FOLR1 Antibody (2B73) can be used in ELISA,ELISA(Cap).
Anti-FOLR1 Antibody (2B73)
Anti-FOLR1 Antibody (2B73)
😃Good
Catalog No. TMAY-01793Alias FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP
Anti-FOLR1 Antibody (2B73) is a Mouse antibody targeting FOLR1. Anti-FOLR1 Antibody (2B73) can be used in ELISA,ELISA(Cap).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $69 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-FOLR1 Antibody (2B73) is a Mouse antibody targeting FOLR1. Anti-FOLR1 Antibody (2B73) can be used in ELISA,ELISA(Cap). |
| Alias | FOLR, folate receptor 1 (adult), Folate Binding Protein, FBP |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 2B73 |
| Reactivity | Human |
| Application | ELISA,ELISA(Cap) |
| Recommended Dose | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FOLR1 (rh FOLR1; TMPY-01815; NP_057937.1; Met1-Met233). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The protein encoded by FOLR1 gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.Folate receptor α (FRα) is the most important subunit of Folate receptor and the alpha isoform has been shown to be selectively overexpressed in cancer types like breast and ovarian cancer compared to normal breast and ovarian epithelial cells. It was determined that Folate receptor α exhibits a limited expression on the apical surfaces of the epithelial cells of normal lung, breast, thyroid, parathyroid, and kidney tissues. For their uptake of folate, normal cells rely almost exclusively on the reduced folate carrier, whereas many carcinomas and myeloid leukemia cells overexpress a high-affinity FR on their surfaces, perhaps reflecting their increased need for folate to support rapid cell division.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human FOLR1 Protein (TMPY-01815) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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