AR-A 2

Name: AR-A 2
Brand: TargetMol
SKU: T10360
Rating: 4.5 (1 reviews)

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Catalog No. T10360Cas No. 220051-79-6

Alias AR-A 000002

AR-A 2 is a selective 5-HT1B receptor antagonist with high affinity to guinea pig cortex 5-HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM), exhibiting a 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

AR-A 2

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Catalog No. T10360Alias AR-A 000002Cas No. 220051-79-6

Pack Size	Price	Availability
25 mg	$1,670	6-8 weeks
50 mg	$2,180	6-8 weeks
100 mg	$2,800	6-8 weeks

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Bioactivity

Description	AR-A 2 is a selective 5-HT1B receptor antagonist with high affinity to guinea pig cortex 5-HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM), exhibiting a 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).
Targets&IC50	5-HT1A receptor (rat hippocampus): 3070 nM , 5-HT1B receptor (guinea pig):（EC50）4.5 nM , 5-HT2A receptor (rat cortex): 339 nM , 5-HT1B/1D receptor (rat cortical): 20 nM , 5-HT1D receptor (guinea pig): 5 nM , α1-adrenoceptor: 490 nM , D2: 330 nM , 5-HT1B receptor (guinea pig): 0.47 nM , 5-HT1B/1D (guinea pig cortex):（ki）0.24 nM
In vitro	AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist, exhibiting an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. It also binds to the rat cortical 5HT1B/1D receptor (Ki: 20 nM), rat cortex 5-HT2A receptor (Ki: 339 nM), rat hippocampus 5-HT1A receptor (Ki: 3070 nM), and shows affinity for dopamine D2 (Ki: 330 nM) and α1-adrenoceptors (Ki: 490 nM).
Synonyms	AR-A 000002

Chemical Properties

Molecular Weight	448.6
Formula	C₂₇H₃₆N₄O₂
Cas No.	220051-79-6
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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