AR-A 2

Name: AR-A 2
Brand: TargetMol
SKU: T10360
Rating: 4.5 (1 reviews)

(Synonyms: AR-A 000002) Copy Product Info

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Synonyms: AR-A 000002

Catalog No. T10360 Copy Product Info

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AR-A 2 is a selective 5-HT1B receptor antagonist with high affinity to guinea pig cortex 5-HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM), exhibiting a 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).

Cas No. 220051-79-6

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,670	6-8 weeks	6-8 weeks
50 mg	$2,180	6-8 weeks	6-8 weeks
100 mg	$2,800	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	AR-A 2 is a selective 5-HT1B receptor antagonist with high affinity to guinea pig cortex 5-HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM), exhibiting a 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).
Targets & IC50	α1-adrenoceptor: 490 nM , 5-HT1A receptor (rat hippocampus): 3070 nM , 5-HT1B/1D (guinea pig cortex):（ki）0.24 nM , 5-HT1B/1D receptor (rat cortical): 20 nM , 5-HT1B receptor (guinea pig): 0.47 nM , D2: 330 nM , 5-HT1B receptor (guinea pig):（EC50）4.5 nM , 5-HT2A receptor (rat cortex): 339 nM , 5-HT1D receptor (guinea pig): 5 nM
In vitro	AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist, exhibiting an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. It also binds to the rat cortical 5HT1B/1D receptor (Ki: 20 nM), rat cortex 5-HT2A receptor (Ki: 339 nM), rat hippocampus 5-HT1A receptor (Ki: 3070 nM), and shows affinity for dopamine D2 (Ki: 330 nM) and α1-adrenoceptors (Ki: 490 nM).
Synonyms	AR-A 000002

Chemical Properties

Molecular Weight	448.6
Formula	C₂₇H₃₆N₄O₂
Cas No.	220051-79-6
Smiles	CC1=C2C(=C(C=C1)N3CCN(C)CC3)C[C@H](NC(=O)C4=CC=C(C=C4)N5CCOCC5)CC2
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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