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MRS-1191

Name: MRS-1191
Brand: TargetMol
SKU: T16134
Rating: 4.5 (1 reviews)

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Catalog No. T16134Cas No. 185222-90-6

MRS-1191 is an effective and selective A3 adenosine receptor antagonist (KB: 92 nM, a Ki: 31.4 nM for human A3 receptor and an IC50: 120 nM for CHO cells).

MRS-1191

😃Good

Catalog No. T16134Cas No. 185222-90-6

MRS-1191 is an effective and selective A3 adenosine receptor antagonist (KB: 92 nM, a Ki: 31.4 nM for human A3 receptor and an IC50: 120 nM for CHO cells).

Pack Size	Price	Availability
25 mg	$670	6-8 weeks
50 mg	$871	6-8 weeks
100 mg	$1,490	6-8 weeks

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Product Introduction

Bioactivity

Description	MRS-1191 is an effective and selective A3 adenosine receptor antagonist (KB: 92 nM, a Ki: 31.4 nM for human A3 receptor and an IC50: 120 nM for CHO cells).
Targets&IC50	A3 receptor (human):(ki)31.4 nM
In vitro	MRS-1191 is found to be competitive in saturation binding studies using the agonist radioligand [125I]AB-MECA (N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methylbromide) at cloned human brain A3 receptor expressed in HEK-293 cells. The effects of putative A3 adenosine receptor antagonist of MRS-1191 is characterized in receptor binding and functional assays. MRS-1191 with a KB value of 92 nM, proves to be highly selective for human A3 receptor vs human A1 receptor-mediated effects on adenylate cyclase .

Chemical Properties

Molecular Weight	477.55
Formula	C₃₁H₂₇NO₄
Cas No.	185222-90-6
Relative Density.	1.23 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (523.51 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0940 mL	10.4701 mL	20.9402 mL	104.7011 mL
5 mM	0.4188 mL	2.0940 mL	4.1880 mL	20.9402 mL
10 mM	0.2094 mL	1.0470 mL	2.0940 mL	10.4701 mL
20 mM	0.1047 mL	0.5235 mL	1.0470 mL	5.2351 mL
50 mM	0.0419 mL	0.2094 mL	0.4188 mL	2.0940 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc