Shopping Cart

Your shopping cart is currently empty

Dolastatin 10

Name: Dolastatin 10
Brand: TargetMol
SKU: TP1180
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. TP1180Cas No. 110417-88-4

Alias NSC 376128, DLS 10

Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

Dolastatin 10

Copy Product Info

😃Good

Purity: 99.00%

Catalog No. TP1180Alias NSC 376128, DLS 10Cas No. 110417-88-4

Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$139	-	In Stock
10 mg	$222	-	In Stock
25 mg	$446	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.00%

Appearance:Solid

Color:White

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.
In vitro	Dolastatin 10, a unique pentapeptide isolated from the sea hare Dolabella auricularia, has GI50 values of 10⁻⁵-10⁻⁶ μg/mL (10⁻²-10⁻³ nM) against a similar minipanel of human cell lines, comparable to Auristatin PE. The antibody-drug conjugate (ADC) consists of the anti-CD30 monoclonal antibody cAC10 conjugated to monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.
Synonyms	NSC 376128, DLS 10

Chemical Properties

Molecular Weight	785.09
Formula	C₄₂H₆₈N₆O₆S
Cas No.	110417-88-4
Smiles	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C
Relative Density.	1.116g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (127.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2737 mL	6.3687 mL	12.7374 mL	63.6870 mL
5 mM	0.2547 mL	1.2737 mL	2.5475 mL	12.7374 mL
10 mM	0.1274 mL	0.6369 mL	1.2737 mL	6.3687 mL
20 mM	0.0637 mL	0.3184 mL	0.6369 mL	3.1843 mL
50 mM	0.0255 mL	0.1274 mL	0.2547 mL	1.2737 mL
100 mM	0.0127 mL	0.0637 mL	0.1274 mL	0.6369 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc