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Anti-HER2/ERBB2 Antibody (2R301)

😃Good
Catalog No. TMAH-00401
Alias TKR1, NGL, NEU, MLN19, MLN 19, HERVW, HERV7Q, herstatin, HER-2, HER2, ERVWE1, ERBB2, ENVW, ENV, EGFR2, CD340

Anti-HER2/ERBB2 Antibody (2R301) is an antibody targeting HER2/ERBB2. Anti-HER2/ERBB2 Antibody (2R301) can be used in ELISA.

Anti-HER2/ERBB2 Antibody (2R301)

Anti-HER2/ERBB2 Antibody (2R301)

😃Good
Catalog No. TMAH-00401Alias TKR1, NGL, NEU, MLN19, MLN 19, HERVW, HERV7Q, herstatin, HER-2, HER2, ERVWE1, ERBB2, ENVW, ENV, EGFR2, CD340
Anti-HER2/ERBB2 Antibody (2R301) is an antibody targeting HER2/ERBB2. Anti-HER2/ERBB2 Antibody (2R301) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
50 μL$207 7-10 days
100 μL$348 7-10 days
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Instruction Manual of Detection Antibody
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Product Introduction

Bioactivity
Description
Antibody Type: Recombinant Monoclonal

Application: ELISA

Reactivity: Human
AliasTKR1, NGL, NEU, MLN19, MLN 19, HERVW, HERV7Q, herstatin, HER-2, HER2, ERVWE1, ERBB2, ENVW, ENV, EGFR2, CD340
Ig Type
Human IgG1
Clone
2R301
Reactivity
Human
Verified Activity
The Binding Activity of Human ERBB2 with Anti-ERBB2 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ERBB2 at 2 μg/mL can bind Anti-ERBB2 recombinant antibody, the EC50 is 2.455-3.565 ng/mL.
Application
ELISA
Antibody Type
Monoclonal
Subcellular Localization[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Early endosome. Cytoplasm, perinuclear region. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
ConstructionRecombinant Antibody
PurificationAffinity-chromatography
AppearanceLiquid
FormulationPreservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
Research BackgroundProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human ERBB2 Protein
Antigen Species
Human
Gene ID
2064
Uniprot ID
Biology Area
Cancer, Tags & Cell Markers, Immunology, Signal transduction
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TKR-1TKR 1MLN-19HER 2ERVWE-1ERVWE 1ERBB-2ERBB 2EGFR-2EGFR 2CD-340CD 340
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