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LEQ506

Name: LEQ506
Brand: TargetMol
SKU: T11838
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11838Cas No. 1204975-42-7

Alias NVP-LEQ506

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

LEQ506

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Purity: 99.76%

Catalog No. T11838Alias NVP-LEQ506Cas No. 1204975-42-7

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

Pack Size	Price	Availability
1 mg	$58	In Stock
5 mg	$148	In Stock
10 mg	$222	In Stock
25 mg	$355	In Stock
50 mg	$479	In Stock
100 mg	$642	In Stock
200 mg	$867	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.76%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
Targets&IC50	Smo (mouse):4 nM , Smo (human):2 nM
In vitro	LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2].
Synonyms	NVP-LEQ506

Chemical Properties

Molecular Weight	432.56
Formula	C₂₅H₃₂N₆O
Cas No.	1204975-42-7
Smiles	C[C@@H]1CN(CCN1c1cnc(cn1)C(C)(C)O)c1nnc(Cc2ccccc2)c(C)c1C
Relative Density.	1.170 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (231.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3118 mL	11.5591 mL	23.1182 mL	115.5909 mL
5 mM	0.4624 mL	2.3118 mL	4.6236 mL	23.1182 mL
10 mM	0.2312 mL	1.1559 mL	2.3118 mL	11.5591 mL
20 mM	0.1156 mL	0.5780 mL	1.1559 mL	5.7795 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	2.3118 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc