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LEQ506

Name: LEQ506
Brand: TargetMol
SKU: T11838
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11838Cas No. 1204975-42-7

Alias NVP-LEQ506

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

LEQ506

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Purity: 99.76%

Catalog No. T11838Alias NVP-LEQ506Cas No. 1204975-42-7

LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$222	In Stock	In Stock
25 mg	$355	In Stock	In Stock
50 mg	$479	In Stock	In Stock
100 mg	$642	In Stock	In Stock
200 mg	$867	-	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	LEQ506 is a Smo inhibitor with IC50s of 2 nM and 4 nM for hSmo and mSmo, respectively.
Targets&IC50	Smo (human):2 nM , Smo (mouse):4 nM
In vitro	LEQ506 consistently decreases Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and 60 to 70% for Ptch1[1]. LEQ506 inhibits Hedgehog signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC50 ~6-fold lower than that of Compound 2[2].
Synonyms	NVP-LEQ506

Chemical Properties

Molecular Weight	432.56
Formula	C₂₅H₃₂N₆O
Cas No.	1204975-42-7
Smiles	C[C@@H]1CN(CCN1c1cnc(cn1)C(C)(C)O)c1nnc(Cc2ccccc2)c(C)c1C
Relative Density.	1.170 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (231.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3118 mL	11.5591 mL	23.1182 mL	115.5909 mL
5 mM	0.4624 mL	2.3118 mL	4.6236 mL	23.1182 mL
10 mM	0.2312 mL	1.1559 mL	2.3118 mL	11.5591 mL
20 mM	0.1156 mL	0.5780 mL	1.1559 mL	5.7795 mL
50 mM	0.0462 mL	0.2312 mL	0.4624 mL	2.3118 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	1.1559 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc