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Casein kinase 1δ-IN-9

Name: Casein kinase 1δ-IN-9
Brand: TargetMol
SKU: T64376
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T64376Cas No. 854355-54-7

Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.

Casein kinase 1δ-IN-9

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Purity: 99.93%

Catalog No. T64376Cas No. 854355-54-7

Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$62	-	In Stock
5 mg	$146	-	In Stock
10 mg	$218	-	In Stock
25 mg	$349	-	In Stock
50 mg	$470	-	In Stock
100 mg	$625	-	In Stock
200 mg	$826	-	In Stock
1 mL x 10 mM (in DMSO)	$133	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.93%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Casein kinase 1δ-IN-9 AI Summary

Casein kinase 1δ-IN-9 exhibits a high level of inhibition (99.0%) against Plasmodium falciparum Dd2 and 3D7 in whole red blood cells based on parasite LDH activity at 2 μM concentration. However, it shows no inhibition (0.0%) against Plasmodium falciparum 3D7 LDH activity in an LDH reporter assay at the same concentration and demonstrates no significant cytotoxicity in the human HepG2 cell line assay at 10 μM. The compound has an XC50 value of 664.32 nM in inhibiting Plasmodium falciparum 3D7 in whole erythrocytes. Additionally, it displays varying levels of bioactivity against multiple targets with EC50 values including: Salmonella typhi (>50000.0 nM), Chronic Active B-Cell Receptor Signaling (11220.2 nM), Vitamin D receptor (89125.1 nM), malarial parasite plastid (465.4 nM at 96-hour, 657.3 nM at 48-hour), TGF-b (12589.3 nM), Hepatitis C Virus (2511.9 nM), and others. It also shows 4.77% to 10.95% inhibition against transgenic Leishmania Mexicana promastigotes at 2 μM concentration. The compound's Inhibition Frequency Index (IFI) is 0.0%, indicating insignificant inhibition in non-kinase HTS assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Casein kinase 1δ-IN-9 is a Quinone reductase 2 inhibitor with IC50 of 0.6μM.

Chemical Properties

Molecular Weight	269.73
Formula	C₁₅H₁₂ClN₃
Cas No.	854355-54-7
Smiles	N(CC1=CC=CC=N1)C=2C3=C(N=CC2)C=C(Cl)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (203.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7074 mL	18.5371 mL	37.0741 mL	185.3706 mL
5 mM	0.7415 mL	3.7074 mL	7.4148 mL	37.0741 mL
10 mM	0.3707 mL	1.8537 mL	3.7074 mL	18.5371 mL
20 mM	0.1854 mL	0.9269 mL	1.8537 mL	9.2685 mL
50 mM	0.0741 mL	0.3707 mL	0.7415 mL	3.7074 mL
100 mM	0.0371 mL	0.1854 mL	0.3707 mL	1.8537 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc