ERB-196

Name: ERB-196
Brand: TargetMol
SKU: T11222
Rating: 4.5 (1 reviews)

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Catalog No. T11222Cas No. 550997-55-2

Alias WAY-202196

Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.

ERB-196

🥰Excellent

Catalog No. T11222Alias WAY-202196Cas No. 550997-55-2

Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.

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Product Introduction

Bioactivity

Description	Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
In vivo	ERB-196 significantly reduces histopathologic evidence of injury to the gastrointestinal mucosal surface (0.7±0.1 vs. 2.3±0.2 for control;?p<0.05).?The mucosal mass of 10-cm segments of small bowel mucosa shows better preservation of mucosal mass than control treatment (63±20 [ERB-196] vs. 31±24 [control]), but this difference fails to reach statistical significance (p<0.06).?The administration of ERB-196 is highly effective in the prevention of lethality.?Consistent with the neutropenic rat model, ERB-196 significantly increases survival when compare with vehicle control.
Synonyms	WAY-202196

Chemical Properties

Molecular Weight	279.27
Formula	C₁₇H₁₀FNO₂
Cas No.	550997-55-2
Smiles	Oc1ccc2cc(cc(C#N)c2c1)-c1ccc(O)c(F)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc