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ZZW-115

Catalog No. T9429 CAS 801991-87-7

ZZW-115 is a potent NUPR1 inhibitor with a Kd of 2.1 μM. ZZW-115 is a derivative of Trifluoperazine (TFP). ZZW-115 shows a dose-dependent tumor regression with no neurological side effects and induces cell death mainly by necroptosis and apoptosis[1] [2].

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ZZW-115, CAS 801991-87-7

Pack Size	Availability	Price/USD	Quantity
25 mg	In stock	$ 1,050.00
50 mg	In stock	$ 1,370.00

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Purity: 99.17%

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Description	ZZW-115 is a potent NUPR1 inhibitor with a Kd of 2.1 μM. ZZW-115 is a derivative of Trifluoperazine (TFP). ZZW-115 shows a dose-dependent tumor regression with no neurological side effects and induces cell death mainly by necroptosis and apoptosis[1] [2].
In vitro	ZZW-115, at concentrations ranging from 0.1 to 100 μM and incubation periods between 24 and 72 hours, demonstrates significant anticancer efficacy by effectively killing a variety of cancer cells. It exhibits IC50 values from as low as 0.42 μM in Hep2G cells to 7.75 μM in SaOS-2 cells, indicating its potency across different cell lines including ANOR, HN14, and others [1]. Moreover, ZZW-115 prompts cancer cell death through both necrosis and apoptosis mechanisms, highlighted by increased lactate dehydrogenase (LDH) release and caspase 3/7 activity in treated cells compared to controls. This is further supported by a decrease in ATP production and an overproduction of reactive oxygen species (ROS), showcasing its dual pro-necrotic and pro-apoptotic actions [1].
In vivo	Administering ZZW-115 via injection at doses ranging from 0.5 to 5 mg/kg daily for 30 days inhibited growth in pancreatic xenografted tumors in NMRI-Foxn1nu/Foxn1nu (nude) mice implanted with MiaPaCa-2 cells. At a dosage of 5 mg/kg, ZZW-115 treatment in immunocompetent C57BL/6 mice orthotopically implanted with Panc02 cells resulted in a significant reduction of tumor size, rendering it almost unmeasurable in some instances. Notably, tumors ceased to grow a few days post-administration of 5 mg/kg ZZW-115 and exhibited a progressive decrease in size, nearing complete disappearance by the treatment's conclusion.

Molecular Weight	464.59
Formula	C24H31F3N4S
CAS No.	801991-87-7

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

ZZW-115 801991-87-7 ZZW 115 ZZW115 inhibitor inhibit

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