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BOS-172722

Name: BOS-172722
Brand: TargetMol
SKU: T14765
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14765Cas No. 1578245-44-9

BOS-172722 is an inhibitor of the monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM.

BOS-172722

🥰Excellent

Purity: 99.37%

Catalog No. T14765Cas No. 1578245-44-9

BOS-172722 is an inhibitor of the monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM.

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$107	In Stock
10 mg	$163	In Stock
25 mg	$328	In Stock
50 mg	$473	In Stock
100 mg	$648	In Stock
200 mg	$873	In Stock

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Purity:99.37%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	BOS-172722 is an inhibitor of the monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM.
Targets&IC50	Mps1:2 nM
In vitro	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM and it also has potential for the treatment of various forms of breast cancer[1].

Chemical Properties

Molecular Weight	446.55
Formula	C₂₄H₃₀N₈O
Cas No.	1578245-44-9
Smiles	CCOc1cc(ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1)-c1nncn1C
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M HCl: 65 mg/mL (145.56 mM), when pH is adjusted to 2 with HCl. Sonication is recommended.

DMSO: < 1.12 mg/mL, Sonication is recommended.

Solution Preparation Table

1M HCl

	1mg	5mg	10mg	50mg
1 mM	2.2394 mL	11.1970 mL	22.3939 mL	111.9695 mL
5 mM	0.4479 mL	2.2394 mL	4.4788 mL	22.3939 mL
10 mM	0.2239 mL	1.1197 mL	2.2394 mL	11.1970 mL
20 mM	0.1120 mL	0.5598 mL	1.1197 mL	5.5985 mL
50 mM	0.0448 mL	0.2239 mL	0.4479 mL	2.2394 mL
100 mM	0.0224 mL	0.1120 mL	0.2239 mL	1.1197 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc