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JKE-1674

Name: JKE-1674
Brand: TargetMol
SKU: T37314
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37314 Copy Product Info

Purity: 98.4%

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JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.

Cas No. 2421119-60-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$44	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$183	In Stock	In Stock
25 mg	$313	In Stock	In Stock
50 mg	$488	In Stock	In Stock
100 mg	$787	In Stock	In Stock
200 mg	$1,070	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$126	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.4%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.
In vitro	JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1].
In vivo	Mice can be orally dosed with JKE-1674 and the compound can be detected in the serum for up to 24 hours.[1]

Chemical Properties

Molecular Weight	451.3
Formula	C₂₀H₂₀Cl₂N₄O₄
Cas No.	2421119-60-8
Smiles	O\N=C(/C[N+]([O-])=O)C(=O)N1CCN(CC1)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (310.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn oil: < 10 mg/mL (22.16 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: < 10 mg/mL (22.16 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% (20% SBE-β-CD in Saline): < 10 mg/mL (22.16 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% Saline: < 10 mg/mL (22.16 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2158 mL	11.0791 mL	22.1582 mL	110.7910 mL
5 mM	0.4432 mL	2.2158 mL	4.4316 mL	22.1582 mL
10 mM	0.2216 mL	1.1079 mL	2.2158 mL	11.0791 mL
20 mM	0.1108 mL	0.5540 mL	1.1079 mL	5.5396 mL
50 mM	0.0443 mL	0.2216 mL	0.4432 mL	2.2158 mL
100 mM	0.0222 mL	0.1108 mL	0.2216 mL	1.1079 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc