Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 113.00 | |
10 mg | In stock | $ 183.00 | |
25 mg | In stock | $ 372.00 | |
50 mg | In stock | $ 597.00 | |
100 mg | In stock | $ 955.00 | |
200 mg | In stock | $ 1,280.00 | |
500 mg | In stock | $ 1,890.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 137.00 |
Description | JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. |
In vitro | JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1]. |
In vivo | JKE-1674 (50?mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound[2]. |
Molecular Weight | 451.3 |
Formula | C20H20Cl2N4O4 |
CAS No. | 2421119-60-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 13 mg/mL (28.81 mM)
You can also refer to dose conversion for different animals. More
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JKE-1674 2421119-60-8 oxidation-reduction GPX ML210 glutathione Ferroptosis peroxidase inhibit JKE1674 JKE 1674 Glutathione Peroxidase rescued Inhibitor inhibitor