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JKE-1674

Catalog No. T37314 CAS 2421119-60-8

JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.

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JKE-1674, CAS 2421119-60-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210.
In vitro	JKE-1674 reduces the viability of LOX-IMVI cancer cells with an EC50 of 0.03 μM and in a panel of additional cancer cell lines. JKE-1674 is completely rescued by ferroptosis inhibitors[1].
In vivo	JKE-1674 (50?mg/kg; p.o.) could be detected in the serum of mice dosed orally with the compound[2].

Molecular Weight	451.3
Formula	C20H20Cl2N4O4
CAS No.	2421119-60-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 13 mg/mL (28.81 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kathman SG, et al. A masked zinger to block GPX4. Nat Chem Biol. 2020;16(5):482-483. 2. Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506.

Related Products

Related compounds with same targets

ML162 ML-210 JKE-1674 RSL3 Misonidazole

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

JKE-1674 2421119-60-8 氧化还原 GPX ML210 glutathione Ferroptosis peroxidase inhibit JKE 1674 Glutathione Peroxidase rescued Inhibitor JKE1674 inhibitor

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