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Diphenyl oxide

Name: Diphenyl oxide
Brand: TargetMol
SKU: T0621
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0621Cas No. 101-84-8

Alias Phenyl ether, Oxydibenzene

Diphenyl oxide (Oxydibenzene) is used in the manufacture of spices and dyes.

Diphenyl oxide

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Purity: 99.82%

Catalog No. T0621Alias Phenyl ether, OxydibenzeneCas No. 101-84-8

Diphenyl oxide (Oxydibenzene) is used in the manufacture of spices and dyes.

Pack Size	Price	USA Warehouse	Global Warehouse
5 g	$34	-	In Stock
10 g	$50	-	In Stock
25 g	$81	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Viscous

Color:Transparent

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COA LCMS HNMR

Product Introduction

Diphenyl oxide AI Summary

Diphenyl oxide inhibits the uptake of L-triiodothyronine (L-T3) by human HepG2 hepatoma cells, showing an inhibitory effect of 22.0% at a dose of 10E-5 M. It has a logP value of 4.2, indicating significant lipophilicity which is crucial for its penetration and distribution within biological systems. The calculated partition coefficient (cLogP) for Diphenyl oxide is reported as both 3.85 and 4.2, suggesting variability but generally confirming the compound's lipid solubility. Additionally, Diphenyl oxide activates aminopeptidase activity of human recombinant leukotriene A4 hydrolase with an AC50 value of 6010.0 nM. Various bioactivities include agonism of the Thyroid Stimulating Hormone Receptor and farnesoid X receptor signaling, with potencies of 7943.3 nM and 4.0 nM, respectively. The compound modulates intracellular cAMP concentrations, exhibits cytotoxic effects, and affects cell viability. It demonstrates activity in the antioxidant response element (ARE) signaling pathway and inhibits Human Apurinic/apyrimidinic Endonuclease 1 (APE1) with a potency of 2238.7 nM. Diphenyl oxide also has a LogD value of 3.5, indicating its distribution coefficient between 1-octanol and D2O..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diphenyl oxide (Oxydibenzene) is used in the manufacture of spices and dyes.
Synonyms	Phenyl ether, Oxydibenzene

Chemical Properties

Molecular Weight	170.21
Formula	C₁₂H₁₀O
Cas No.	101-84-8
Smiles	O(C1=CC=CC=C1)C1=CC=CC=C1
Relative Density.	1.073 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (293.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8751 mL	29.3755 mL	58.7510 mL	293.7548 mL
5 mM	1.1750 mL	5.8751 mL	11.7502 mL	58.7510 mL
10 mM	0.5875 mL	2.9375 mL	5.8751 mL	29.3755 mL
20 mM	0.2938 mL	1.4688 mL	2.9375 mL	14.6877 mL
50 mM	0.1175 mL	0.5875 mL	1.1750 mL	5.8751 mL
100 mM	0.0588 mL	0.2938 mL	0.5875 mL	2.9375 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc