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Desformylflustrabromine hydrochloride

🥰Excellent
Catalog No. T11004Cas No. 951322-11-5
Alias dFBr hydrochloride, Deformylflustrabromine hydrochloride

Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.

Desformylflustrabromine hydrochloride

Desformylflustrabromine hydrochloride

🥰Excellent
Purity: 98.12%
Catalog No. T11004Alias dFBr hydrochloride, Deformylflustrabromine hydrochlorideCas No. 951322-11-5
Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$48In StockIn Stock
10 mg$77In StockIn Stock
25 mg$156In StockIn Stock
50 mg$249In StockIn Stock
100 mg$392In StockIn Stock
200 mg$610In StockIn Stock
1 mL x 10 mM (in DMSO)$55In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.12%
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Product Introduction

Bioactivity
Description
Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
Targets&IC50
nAChR:6.48(pEC50)
In vitro
Desformylflustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).[2]
ACh-induced currents are potentiated and inhibited by Desformylflustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform (pEC50=6.4±0.2) compare with the HS isoform (pEC50=5.6±0.2).[2]
SynonymsdFBr hydrochloride, Deformylflustrabromine hydrochloride
Chemical Properties
Molecular Weight437.19
FormulaC17H12INO5
Cas No.951322-11-5
SmilesCl.CNCCc1c([nH]c2cc(Br)ccc12)C(C)(C)C=C
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 4.5 mg/mL (12.6 mM), Sonication is recommended.
DMSO: 94.5 mg/mL (216.15 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.55 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.2873 mL11.4367 mL22.8734 mL114.3668 mL
5 mM0.4575 mL2.2873 mL4.5747 mL22.8734 mL
10 mM0.2287 mL1.1437 mL2.2873 mL11.4367 mL
DMSO
1mg5mg10mg50mg
20 mM0.1144 mL0.5718 mL1.1437 mL5.7183 mL
50 mM0.0457 mL0.2287 mL0.4575 mL2.2873 mL
100 mM0.0229 mL0.1144 mL0.2287 mL1.1437 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

α4β2 nAChRnAChRdFBr HydrochlorideDesformylflustrabromine HydrochlorideDeformylflustrabromine Hydrochloride
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