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Biotin-PEG4-alkyne

Name: Biotin-PEG4-alkyne
Brand: TargetMol
SKU: T14598
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T14598 Copy Product Info

Purity: 99.25%

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Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.

Biotin-PEG4-alkyne

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Catalog No. T14598

Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.

Cas No. 1458576-00-5

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Pack Size	Price	USA Stock	Global Stock
10 mg	$30	In Stock	In Stock
25 mg	$46	In Stock	In Stock
50 mg	$78	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.25%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.
In vitro	PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	457.58
Formula	C₂₁H₃₅N₃O₆S
Cas No.	1458576-00-5
Smiles	C(CCCC(NCCOCCOCCOCCOCC#C)=O)[C@@H]1[C@]2([C@@](CS1)(NC(=O)N2)[H])[H]
Relative Density.	1.158 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (546.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1854 mL	10.9271 mL	21.8541 mL	109.2705 mL
5 mM	0.4371 mL	2.1854 mL	4.3708 mL	21.8541 mL
10 mM	0.2185 mL	1.0927 mL	2.1854 mL	10.9271 mL
20 mM	0.1093 mL	0.5464 mL	1.0927 mL	5.4635 mL
50 mM	0.0437 mL	0.2185 mL	0.4371 mL	2.1854 mL
100 mM	0.0219 mL	0.1093 mL	0.2185 mL	1.0927 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc