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Biotin-PEG4-alkyne

Biotin-PEG4-alkyne
Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.
Catalog No. T14598Cas No. 1458576-00-5
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Biotin-PEG4-alkyne

Catalog No. T14598Cas No. 1458576-00-5

Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.
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Pack SizePriceAvailabilityQuantity
5 mg$182In Stock
10 mg$42In Stock
25 mg$46In Stock
50 mg$78In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Product Introduction

Bioactivity
Description
Biotin-PEG4-alkyne is a biotin-labeled, polyethylene glycol-based (PEG-based) PROTAC linker utilized in PROTAC synthesis.
In vitro
PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Chemical Properties
Molecular Weight457.58
FormulaC21H35N3O6S
Cas No.1458576-00-5
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (218.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1854 mL10.9271 mL21.8541 mL109.2705 mL
5 mM0.4371 mL2.1854 mL4.3708 mL21.8541 mL
10 mM0.2185 mL1.0927 mL2.1854 mL10.9271 mL
20 mM0.1093 mL0.5464 mL1.0927 mL5.4635 mL
50 mM0.0437 mL0.2185 mL0.4371 mL2.1854 mL
100 mM0.0219 mL0.1093 mL0.2185 mL1.0927 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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