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Anti-GABA B Receptor 2 Antibody (1L8) is a Mouse antibody targeting GABA B Receptor 2. Anti-GABA B Receptor 2 Antibody (1L8) can be used in WB,IP,IF.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $298 | 7-10 days | |
100 μL | $426 | 7-10 days |
Description | Anti-GABA B Receptor 2 Antibody (1L8) is a Mouse antibody targeting GABA B Receptor 2. Anti-GABA B Receptor 2 Antibody (1L8) can be used in WB,IP,IF. |
Synonyms | R2 SUBUNIT, OTTHUMP00000063797, OTTHUMP00000021776, Metabotropic GABA B receptor subtype 2, HRIHFB2099, HG20, HG 20, G-protein coupled receptor 51, GPRC3B, GPRC 3B, GPR51, GPR 51, GH07312, Gb2, Gb 2, Gamma-aminobutyric acid type B receptor subunit 2, Gamma aminobutyric acid type B receptor subunit 2, Gamma aminobutyric acid GABA B receptor 2, Gamma aminobutyric acid B receptor 2, GABR2_HUMAN, Gabbr2, GABBR 2, GABB R2, GABA-B-R2, GABA-BR2, GABABR2, GABABR 2, GABA-B receptor 2, GABAB R2, GABA B receptor 2, GABA B R2, GAB B R2, G protein coupled receptor 51, FLJ36928, D Gaba2, CT20836, CG6706, BcDNA:GH07312 |
Reactivity | Human,Mouse,Rat |
Verified Activity | 1. Western blot analysis of GABAB R2 expression in mouse brain (A) and rat brain (B) tissue extracts. |
Application | |
Recommended Dose | WB: 1:100-1000; IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | In the central nervous system (CNS), γ-aminobutyric acid (GABA) is the maininhibitory neurotransmitter that functions to regulate neuronal firing. GABAexerts its effects through two different kinds of receptors: ionotropic receptors(GABAA R and GABAC R), which produce fast inhibitory signals, and metabotropicreceptors (GABAB R), which produce slow inhibitory signals. TheGABAB R receptor is a heterodimer that consists of two multi-pass membraneproteins, designated GABAB R1 and GABAB R2, both of which belong to theG protein-coupled receptor family and are highly expressed in brain tissue.Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning ofinhibitory synaptic transmissions and are implicated in slow wave sleep,muscle relaxation, hippocampal long-term potentiation and antinociceptionevents. Both GABAB R1 and GABAB R2 are regulated by G proteins that havea variety of functions, including activation of potassium channels, inhibitionof adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipidhydrolysis. |
Conjucates | Unconjugated |
Immunogen | Amino acids 183-482 mapping within an extracellular domain of GABA(B) R2 of human origin |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Theoretical: 130 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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