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Anti-IFIH1 Antibody (8B90)
😃Good
Catalog No. TMAH-00592
Anti-IFIH1 Antibody (8B90) is an antibody targeting IFIH1. Anti-IFIH1 Antibody (8B90) can be used in ELISA,WB.
Anti-IFIH1 Antibody (8B90)
Anti-IFIH1 Antibody (8B90)
😃Good
Catalog No. TMAH-00592
Anti-IFIH1 Antibody (8B90) is an antibody targeting IFIH1. Anti-IFIH1 Antibody (8B90) can be used in ELISA,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-IFIH1 Antibody (8B90) is an antibody targeting IFIH1. Anti-IFIH1 Antibody (8B90) can be used in ELISA,WB. |
| Ig Type | Rabbit IgG |
| Clone | 8B90 |
| Reactivity | Human, Mouse |
| Verified Activity | Western Blot -Positive WB detected in: THP-1 whole cell lysate, Mouse lung tissue -All lanes: MDA5 antibody at 1:2000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 117, 26 kDa -Observed band size: 117 kDa |
| Application | |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Mitochondrion. Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis. |
| Tissue Specificity | Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Detects coronavirus SARS-CoV-2. Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human MDA5 |
| Antigen Species | Human |
| Gene Name | IFIH1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Immunology, Microbiology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Keywords
RNA helicase-DEAD box protein 116RLR-2RLR2RIG-I-like receptor 2 (RLR-2)RH116RH 116Murabutide down-regulated proteinMelanoma differentiation-associated protein 5 (MDA-5)MDA-5MDA5MDA 5Interferon-induced with helicase C domain protein 1Interferon-induced helicase C domain-containing protein 1IFIH1IFIH 1Helicase with 2 CARD domains (Helicard)HelicardClinically amyopathic dermatomyositis autoantigen 140 kDa (CADM-140 autoantigen)CADM-140 autoantigenCADM140 autoantigen
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