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NF-κΒ activator 1

🥰Excellent
Catalog No. T39965Cas No. 2387524-59-4

NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 1 mRNA expression.

NF-κΒ activator 1

NF-κΒ activator 1

🥰Excellent
Purity: 99.58%
Catalog No. T39965Cas No. 2387524-59-4
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 1 mRNA expression.
Pack SizePriceAvailabilityQuantity
1 mg$87In Stock
5 mg$213In Stock
10 mg$347In Stock
25 mg$589In Stock
50 mg$842In Stock
100 mg$1,160In Stock
500 mg$2,330In Stock
1 mL x 10 mM (in DMSO)$235In Stock
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Purity:99.58%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 1 mRNA expression.
Targets&IC50
NF-κB:0.9 μM (EC50)
In vitro
NF-κΒ activator 1 (compound 32) (1 μM; 6 hours) accelerates SOD2 mRNA expression in SH-SY5Y neuroblastoma cells [1] .
Chemical Properties
Molecular Weight314.33
FormulaC16H11FN2O2S
Cas No.2387524-59-4
SmilesOC(=O)c1cccc(c1)-c1csc(Nc2ccccc2F)n1
Relative Density.1.427 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 112.5 mg/mL (357.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1814 mL15.9068 mL31.8137 mL159.0685 mL
5 mM0.6363 mL3.1814 mL6.3627 mL31.8137 mL
10 mM0.3181 mL1.5907 mL3.1814 mL15.9068 mL
20 mM0.1591 mL0.7953 mL1.5907 mL7.9534 mL
50 mM0.0636 mL0.3181 mL0.6363 mL3.1814 mL
100 mM0.0318 mL0.1591 mL0.3181 mL1.5907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

NF-κΒ activator 1NFκΒ activator 1NF-κBNFκBNF-kb activator 1NF-kBNFkBNF-kappabeta activator 1NF κΒ activator 1
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