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Fraxin

Name: Fraxin
Brand: TargetMol
SKU: T3783
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3783Cas No. 524-30-1

Alias Paviin, Fraxoside, Fraxetin-8-O-glucoside

Fraxin (Fraxoside) is a glucoside of fraxetin.

Fraxin

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Purity: 99.94%

Catalog No. T3783Alias Paviin, Fraxoside, Fraxetin-8-O-glucosideCas No. 524-30-1

Fraxin (Fraxoside) is a glucoside of fraxetin.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$44	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$313	In Stock	In Stock
100 mg	$469	-	In Stock
200 mg	$676	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Fraxin AI Summary

Fraxin exhibits a broad spectrum of bioactivity, including inhibitory effects on a variety of cellular processes and molecular targets. It shows potent inhibitory effects against Proteus mirabilis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa with a MIC90 range of 1450.0 µg/mL. Additionally, Fraxin targets multiple cellular pathways, including GCN5L2, RanGTP-induced Rango-importin beta complex dissociation, Polymerase Iota, Mammalian Selenoprotein Thioredoxin Reductase 1, DNA re-replication in normal and cancer cells, GLP-1 receptor inverse agonists, Glutaminase, ATXN expression, and USP1/UAF1. It also exhibits inhibitory activity against various human carbonic anhydrase isoforms, with the highest affinity for carbonic anhydrase 9 (Ki: 370.0 nM) and relatively lower affinities for carbonic anhydrases 7, 1, 12, and 13 (Ki: 3870.0 nM, 5040.0 nM, 7450.0 nM, and 9800.0 nM, respectively). These diverse bioactivities suggest that Fraxin holds potential for inhibiting a range of bacterial and enzymatic targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Fraxin (Fraxoside) is a glucoside of fraxetin.
Synonyms	Paviin, Fraxoside, Fraxetin-8-O-glucoside

Chemical Properties

Molecular Weight	370.31
Formula	C₁₆H₁₈O₁₀
Cas No.	524-30-1
Smiles	COc1cc2ccc(=O)oc2c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1O
Relative Density.	1.4066 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (135.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7004 mL	13.5022 mL	27.0044 mL	135.0220 mL
5 mM	0.5401 mL	2.7004 mL	5.4009 mL	27.0044 mL
10 mM	0.2700 mL	1.3502 mL	2.7004 mL	13.5022 mL
20 mM	0.1350 mL	0.6751 mL	1.3502 mL	6.7511 mL
50 mM	0.0540 mL	0.2700 mL	0.5401 mL	2.7004 mL
100 mM	0.0270 mL	0.1350 mL	0.2700 mL	1.3502 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc