Thioproperazine

Name: Thioproperazine
Brand: TargetMol
SKU: T21368
Price: 739 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21368Cas No. 316-81-4

Alias SKF 5883, RP 7843, Megeptil, Mazeptyl, Majeptyl, Cephalmin

Thioproperazine (RP 7843) is an orally effective antipsychotic also used as a tranquilizer and antiemetic for the treatment of schizophrenia and the manic phase of bipolar disorder, acting as a histamine and adrenergic receptor blocker.

Thioproperazine

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Catalog No. T21368Alias SKF 5883, RP 7843, Megeptil, Mazeptyl, Majeptyl, CephalminCas No. 316-81-4

Pack Size	Price	Availability	Quantity
50 mg	$739	In Stock
100 mg	$1,110	In Stock

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Product Introduction

Bioactivity

Description	Thioproperazine (RP 7843) is an orally effective antipsychotic also used as a tranquilizer and antiemetic for the treatment of schizophrenia and the manic phase of bipolar disorder, acting as a histamine and adrenergic receptor blocker.
In vitro	Thioproperazine (5 mg/kg) pretreatment in rats significantly increased ³H-dopamine synthesis and release in striatal slices (by 88% and 49%, respectively)[1].
Alias	SKF 5883, RP 7843, Megeptil, Mazeptyl, Majeptyl, Cephalmin

Chemical Properties

Molecular Weight	446.63
Formula	C₂₂H₃₀N₄O₂S₂
Cas No.	316-81-4
Smiles	O=S(=O)(C1=CC=C2SC=3C=CC=CC3N(C2=C1)CCCN4CCN(C)CC4)N(C)C
Relative Density.	1.1476 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble)

DMSO: 10 mg/mL (22.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2390 mL	11.1949 mL	22.3899 mL	111.9495 mL
5 mM	0.4478 mL	2.2390 mL	4.4780 mL	22.3899 mL
10 mM	0.2239 mL	1.1195 mL	2.2390 mL	11.1949 mL
20 mM	0.1119 mL	0.5597 mL	1.1195 mL	5.5975 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc