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Anti-NGFR/p75NTR Antibody (5K63)
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Catalog No. TMAY-03502
Alias nerve growth factor receptor (TNFR superfamily, member 16)
Anti-NGFR/p75NTR Antibody (5K63) is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Antibody (5K63) can be used in WB,ELISA.
Anti-NGFR/p75NTR Antibody (5K63)
Anti-NGFR/p75NTR Antibody (5K63)
😃Good
Catalog No. TMAY-03502Alias nerve growth factor receptor (TNFR superfamily, member 16)
Anti-NGFR/p75NTR Antibody (5K63) is a Rabbit antibody targeting NGFR/p75NTR. Anti-NGFR/p75NTR Antibody (5K63) can be used in WB,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: WB, ELISA Reactivity: Mouse |
| Alias | nerve growth factor receptor (TNFR superfamily, member 16) |
| Ig Type | Rabbit IgG |
| Clone | 5K63 |
| Reactivity | Mouse |
| Verified Activity | Anti-NGFR rabbit monoclonal antibody at 1:500 -Lane A: Rat Brain Tissue Lysate. -Lane B: Mouse Brain Tissue Lysate. -Lane C: Mouse Heart Tissue lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:45 kDa. -Observed band size:51 kDa(We are unsure as to the identity of these extra bands.) |
| Application | WB,ELISA |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:25000-1:50000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse NGFR / P75 (rM NGFR / P75; TMPY-02541; Q9Z0W1; Met1-Asn243). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. The high-affinity nerve growth factor receptor is also referred to as the Trk family whose members are bound by some neurotrophins with high affinity.Nerve growth factorbinds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to the cell body. The Low-affinity nerve growth factor receptor also named p75 which binds with all kinds of neurotrophins with low affinity. All four kinds of neurotrophins, including Nerve growth factor, Brain-derived neurotrophic factor, Neurotrophin-3, and Neurotrophin-4 bind to the p75. Studies have proved that NGFR acts as a molecular signal switch that determines cell death or survival by three steps. First, pro-nerve growth factor (prNGF) triggers cell apoptosis by its high-affinity binding to p75NTR, while NGF induces neuronal survival with low-affinity binding. Second, p75NTR mediates cell death by combining with co-receptor Sortilin, whereas it promotes neuronal survival through combination with proNGF. Third, the release of the intracellular domain chopper or cleavage short p75 NTR can independently initiate neuronal apoptosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse NGFR / P75 Protein (TMPY-02541) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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