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endo-BCN-PEG3-NH2

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Catalog No. T17936Cas No. 1883512-27-3

endo-BCN-PEG3-NH2 is a PEG-based linker used in PROTACs (proteolysis targeting chimeras) that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

endo-BCN-PEG3-NH2

endo-BCN-PEG3-NH2

😃Good
Catalog No. T17936Cas No. 1883512-27-3
endo-BCN-PEG3-NH2 is a PEG-based linker used in PROTACs (proteolysis targeting chimeras) that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
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Product Introduction

Bioactivity
Description
endo-BCN-PEG3-NH2 is a PEG-based linker used in PROTACs (proteolysis targeting chimeras) that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro
PROTACs are composed of two distinct ligands linked together: one targets an E3 ubiquitin ligase, and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system for selective protein degradation[1].
Chemical Properties
Molecular Weight368.47
FormulaC19H32N2O5
Cas No.1883512-27-3
Relative Density.1.14 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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Keywords

PEGsendo-BCN-PEG3-NH2endo-BCN-PEG-3-NH2endoBCNPEG3NH2endo BCN PEG3 NH2
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