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PKCTheta-IN-2

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Catalog No. T201189Cas No. 1810742-60-9
Alias PKCθ-IN-2

PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).

PKCTheta-IN-2

PKCTheta-IN-2

😃Good
Purity: 99.38%
Catalog No. T201189Alias PKCθ-IN-2Cas No. 1810742-60-9
PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30-In Stock
5 mg$64-In Stock
10 mg$98-In Stock
25 mg$197-In Stock
50 mg$297-In Stock
100 mg$479-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.38%
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Product Introduction

Bioactivity
Description
PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).
Targets&IC50
PKCθ:0.25 nM, IL-2 (mouse):682 nM
SynonymsPKCθ-IN-2
Chemical Properties
Molecular Weight413.47
FormulaC24H23N5O2
Cas No.1810742-60-9
Smiles[C@H](C)(N1C=2C(C(=O)NC1(C)C)=CC=C(C2)N3C=4C(NC3=O)=NC=CC4)C5=CC=CC=C5
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (241.86 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4186 mL12.0928 mL24.1856 mL120.9278 mL
5 mM0.4837 mL2.4186 mL4.8371 mL24.1856 mL
10 mM0.2419 mL1.2093 mL2.4186 mL12.0928 mL
20 mM0.1209 mL0.6046 mL1.2093 mL6.0464 mL
50 mM0.0484 mL0.2419 mL0.4837 mL2.4186 mL
100 mM0.0242 mL0.1209 mL0.2419 mL1.2093 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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