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BMS-195270

Name: BMS-195270
Brand: TargetMol
SKU: T30503
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30503Cas No. 202822-23-9

Alias UNII-20UM0T170J, SCHEMBL5754043, CHEMBL13637, BMS195270, BMS 195270

BMS-195270 is a tissue-specific inhibitor of bladder muscle tone and spontaneous contraction in rats. It can inhibit Carbachol-induced tone and inhibit calcium flux in isolated rat bladder tissue strips in an isolated bladder model.

BMS-195270

😃Good

Purity: 98.7%

Catalog No. T30503Alias UNII-20UM0T170J, SCHEMBL5754043, CHEMBL13637, BMS195270, BMS 195270Cas No. 202822-23-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$35	In Stock	In Stock
5 mg	$86	In Stock	In Stock
10 mg	$137	In Stock	In Stock
25 mg	$278	In Stock	In Stock
50 mg	$447	In Stock	In Stock
100 mg	$592	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.7%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BMS-195270 is a tissue-specific inhibitor of bladder muscle tone and spontaneous contraction in rats. It can inhibit Carbachol-induced tone and inhibit calcium flux in isolated rat bladder tissue strips in an isolated bladder model.
In vitro	BMS-195270 inhibited the response of HEK293 cells to the muscarinic agonist carbachol (the EC50 was 2 μM)[1].
Synonyms	UNII-20UM0T170J, SCHEMBL5754043, CHEMBL13637, BMS195270, BMS 195270

Chemical Properties

Molecular Weight	355.7
Formula	C₁₅H₉ClF₃N₃O₂
Cas No.	202822-23-9
Smiles	O=C1NC(=NN1C2=CC(Cl)=CC=C2O)C=3C=CC=CC3C(F)(F)F
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (281.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8114 mL	14.0568 mL	28.1136 mL	140.5679 mL
5 mM	0.5623 mL	2.8114 mL	5.6227 mL	28.1136 mL
10 mM	0.2811 mL	1.4057 mL	2.8114 mL	14.0568 mL
20 mM	0.1406 mL	0.7028 mL	1.4057 mL	7.0284 mL
50 mM	0.0562 mL	0.2811 mL	0.5623 mL	2.8114 mL
100 mM	0.0281 mL	0.1406 mL	0.2811 mL	1.4057 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc