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BMS-195270

Name: BMS-195270
Brand: TargetMol
SKU: T30503
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T30503Cas No. 202822-23-9

Alias UNII-20UM0T170J, SCHEMBL5754043, CHEMBL13637, BMS195270, BMS 195270

BMS-195270 is a tissue-specific inhibitor of bladder muscle tone and spontaneous contraction in rats. It can inhibit Carbachol-induced tone and inhibit calcium flux in isolated rat bladder tissue strips in an isolated bladder model.

BMS-195270

🥰Excellent

Purity: 98.7%

Catalog No. T30503Alias UNII-20UM0T170J, SCHEMBL5754043, CHEMBL13637, BMS195270, BMS 195270Cas No. 202822-23-9

Pack Size	Price	Availability
1 mg	$59	In Stock
5 mg	$143	In Stock
10 mg	$228	In Stock
25 mg	$463	In Stock
50 mg	$745	In Stock
100 mg	$987	In Stock

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Batch Information

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Purity:98.7%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BMS-195270 is a tissue-specific inhibitor of bladder muscle tone and spontaneous contraction in rats. It can inhibit Carbachol-induced tone and inhibit calcium flux in isolated rat bladder tissue strips in an isolated bladder model.
In vitro	BMS-195270 inhibited the response of HEK293 cells to the muscarinic agonist carbachol (the EC50 was 2 μM)[1].
Synonyms	UNII-20UM0T170J, SCHEMBL5754043, CHEMBL13637, BMS195270, BMS 195270

Chemical Properties

Molecular Weight	355.7
Formula	C₁₅H₉ClF₃N₃O₂
Cas No.	202822-23-9
Smiles	O=C1NC(=NN1C2=CC(Cl)=CC=C2O)C=3C=CC=CC3C(F)(F)F
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (281.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8114 mL	14.0568 mL	28.1136 mL	140.5679 mL
5 mM	0.5623 mL	2.8114 mL	5.6227 mL	28.1136 mL
10 mM	0.2811 mL	1.4057 mL	2.8114 mL	14.0568 mL
20 mM	0.1406 mL	0.7028 mL	1.4057 mL	7.0284 mL
50 mM	0.0562 mL	0.2811 mL	0.5623 mL	2.8114 mL
100 mM	0.0281 mL	0.1406 mL	0.2811 mL	1.4057 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc