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Sanguinarine
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Catalog No. T2781Cas No. 2447-54-3
Alias Sanguinarin, Pseudochelerythrine
Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.
Sanguinarine
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Purity: 99.76%
Catalog No. T2781Alias Sanguinarin, PseudochelerythrineCas No. 2447-54-3
Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $94 | In Stock | In Stock | |
| 5 mg | $173 | In Stock | In Stock | |
| 10 mg | $258 | In Stock | In Stock | |
| 25 mg | $437 | In Stock | In Stock | |
| 50 mg | $628 | In Stock | - | |
| 100 mg | $889 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $192 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.76%
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Product Introduction
Sanguinarine AI Summary
Sanguinarine exhibits a wide range of bioactivities across various biological systems. It demonstrates significant inhibitory activity against alanine aminotransferase (ID50 of 0.0000034 M) and can completely inactivate it at 0.00005 M. It forms stable complexes with thioethanol, cysteine, and glutathione, indicating potential interactions. The compound induces relaxation in isolated guinea pig trachea (-89.0% relaxation) and shows diverse antimicrobial activity with MIC values ranging from 2.0 to 15.0 µg/mL against various bacteria, including Streptococcus mutans, Porphyromonas gingivalis, and Staphylococcus species. It exhibits potent inhibition of acetylcholinesterase (IC50 of 1220.0 nM) and moderate inhibition of butyrylcholinesterase. Moreover, Sanguinarine has demonstrated inhibition of human Bcl-XL (IC50 of 19000.0 nM), human liver enzymes, HDAC6, and NF-kappaB transactivation in TNF-alpha-stimulated K562 cells. It induces apoptosis in human T24 cells via caspase-3-mediated DEVDase activity and has shown cytotoxicity against human THLE, MKN45, and NB4 cells. The compound also affects P-glycoprotein activity, enhancing doxorubicin-induced cytotoxicity, and inhibits rat UT-A1, affecting urea transport. Additionally, it has potential antibacterial applications by inhibiting FtsZ activity, crucial for bacterial cell division. These diverse bioactivities suggest that Sanguinarine could be a valuable candidate for further pharmacological and antimicrobial research..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sanguinarine (Pseudochelerythrine) is a specific inhibitor of Rac1b with anti-microbial, anti-oxidant and anti-inflammatory properties. |
| Synonyms | Sanguinarin, Pseudochelerythrine |
| Molecular Weight | 332.33 |
| Formula | C20H14NO4 |
| Cas No. | 2447-54-3 |
| Smiles | C[N+]=1C2=C(C=3C(C1)=C4C(=CC3)OCO4)C=CC=5C2=CC6=C(C5)OCO6 |
| Relative Density. | 1.3463 g/cm3 (Estimated) |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.33 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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