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PFI-90

Name: PFI-90
Brand: TargetMol
SKU: T9243
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9243Cas No. 53995-62-3

PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death.

PFI-90

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Purity: 99.46%

Catalog No. T9243Cas No. 53995-62-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$34	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.46%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death.
Targets&IC50	RH30:3200nM, RH4:812 nM, TC-32 cells:1113nM, OSA-CL cells:1895nM
In vitro	PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].

Chemical Properties

Molecular Weight	214.22
Formula	C₁₁H₁₀N₄O
Cas No.	53995-62-3
Smiles	O=C(NNc1ccccn1)c1ccccn1
Relative Density.	1.309 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 20 mg/mL (93.36 mM), Sonication and heating are recommended.

DMSO: 125 mg/mL (583.51 mM), Sonication is recommended.

H2O: insoluble

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6681 mL	23.3405 mL	46.6810 mL	233.4049 mL
5 mM	0.9336 mL	4.6681 mL	9.3362 mL	46.6810 mL
10 mM	0.4668 mL	2.3340 mL	4.6681 mL	23.3405 mL
20 mM	0.2334 mL	1.1670 mL	2.3340 mL	11.6702 mL
50 mM	0.0934 mL	0.4668 mL	0.9336 mL	4.6681 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0467 mL	0.2334 mL	0.4668 mL	2.3340 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc