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Oxybutynin

Name: Oxybutynin
Brand: TargetMol
SKU: T1049L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1049LCas No. 5633-20-5

Alias Oxytrol, Oxibutyninum, Ditropan

Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.

Oxybutynin

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Purity: 99.57%

Catalog No. T1049LAlias Oxytrol, Oxibutyninum, DitropanCas No. 5633-20-5

Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$35	In Stock	In Stock
100 mg	$47	In Stock	In Stock
500 mg	$98	In Stock	In Stock
1 g	$148	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.57%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Oxybutynin AI Summary

Oxybutynin exhibits diverse bioactivities, demonstrating notable affinity and inhibitory actions at various muscarinic acetylcholine receptor subtypes M1, M2, and M3, with Kb values of 10.0 nM, 98.0 nM, and 9.0 nM, respectively. It shows robust binding to M1 and M3 receptors, with Ki values of 1.0 nM and 0.78 nM, and some affinity for the M2 receptor (Ki = 8.1 nM). In animal models, it effectively inhibits urinary bladder contraction (ID50 = 0.038 mg.kg-1) and salivation (ID50 = 0.11 mg.kg-1). Additionally, it has compelling activity against the MES-SA/DX5 cell line, impacts mitochondrial dynamics, demonstrates antiviral potential against SARS-CoV-2, and influences various other targets including L-type calcium channels, Acid Sphingomyelinase, OCT1, BSEP, and several histone lysine methyltransferases. Pharmacokinetically, it exhibits a moderate half-life, low volume of distribution, high plasma protein binding, and shows enzyme inhibition including CYP2C19, suggesting intricate interplay within metabolic pathways. These bioactivities indicate its potential for treating conditions associated with cholinergic signaling, viral infections, and other pathophysiological processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxybutynin (Ditropan) is a synthetic anticholinergic agent that is used for treatment of urinary incontinence and overactive bladder syndrome.
In vitro	In human liver microsomes, Oxybutynin inhibits CYP3A4- and CYP2D6-associated activities (testosterone 6β-hydroxylase and dextromethorphan O-demethylase, respectively).Oxybutynin (30,100 nM) competitively antagonizes acetylcholine-induced contraction.
In vivo	In human liver microsomes, Oxybutynin inhibits CYP3A4- and CYP2D6-associated activities (testosterone 6β-hydroxylase and dextromethorphan O-demethylase, respectively).Oxybutynin (30,100 nM) competitively antagonizes acetylcholine-induced contraction.
Synonyms	Oxytrol, Oxibutyninum, Ditropan

Chemical Properties

Molecular Weight	357.49
Formula	C₂₂H₃₁NO₃
Cas No.	5633-20-5
Smiles	C(C(OCC#CCN(CC)CC)=O)(O)(C1CCCCC1)C2=CC=CC=C2
Relative Density.	1.097 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 66 mg/mL (184.62 mM), Sonication is recommended.

DMSO: 45 mg/mL (125.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.7973 mL	13.9864 mL	27.9728 mL	139.8641 mL
5 mM	0.5595 mL	2.7973 mL	5.5946 mL	27.9728 mL
10 mM	0.2797 mL	1.3986 mL	2.7973 mL	13.9864 mL
20 mM	0.1399 mL	0.6993 mL	1.3986 mL	6.9932 mL
50 mM	0.0559 mL	0.2797 mL	0.5595 mL	2.7973 mL
100 mM	0.0280 mL	0.1399 mL	0.2797 mL	1.3986 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc