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Anti-Phospho-RPA2 (Thr21) Antibody (7P562)
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Catalog No. TMAH-00958
Alias RPA2 (p-Thr21), RPA2 (p-T21), p-RPA2 (Thr21), p-RPA2 (T21), Phospho-RPA2 (T21)
Anti-Phospho-RPA2 (Thr21) Antibody (7P562) is an antibody targeting Phospho-RPA2 (Thr21). Anti-Phospho-RPA2 (Thr21) Antibody (7P562) can be used in ELISA, IF.
Anti-Phospho-RPA2 (Thr21) Antibody (7P562)
Anti-Phospho-RPA2 (Thr21) Antibody (7P562)
😃Good
Catalog No. TMAH-00958Alias RPA2 (p-Thr21), RPA2 (p-T21), p-RPA2 (Thr21), p-RPA2 (T21), Phospho-RPA2 (T21)
Anti-Phospho-RPA2 (Thr21) Antibody (7P562) is an antibody targeting Phospho-RPA2 (Thr21). Anti-Phospho-RPA2 (Thr21) Antibody (7P562) can be used in ELISA, IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $348 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IF Reactivity: Human |
| Alias | RPA2 (p-Thr21), RPA2 (p-T21), p-RPA2 (Thr21), p-RPA2 (T21), Phospho-RPA2 (T21) |
| Ig Type | Rabbit IgG |
| Clone | 7P562 |
| Reactivity | Human |
| Verified Activity | Immunofluorescence staining of Hela cells with TMAH-00958 at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| Application | ELISA, IF |
| Recommended Dose | IF:1:20-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. Nucleus, PML body. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-RPA2 (T21) |
| Antigen Species | Human |
| Gene ID | 6118 |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
RPA34RPA32RPA2 (pThr21)RPA2 (pT21)RPA2 (phospho-Thr21)RPA2 (phospho-T21)RPA2RP-A p34RPA p34RP-A p32RPA p32RPA 34RPA 32RPA 2RF-A protein2RF-A protein 2Replication protein A 34 kDa subunit (RP-A p34)Replication protein A 32 kDa subunitReplication factor A protein 2 (RF-A protein 2)REPA2REPA 2pRPA2 (Thr21)pRPA2 (T21)
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