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BMS-8

Name: BMS-8
Brand: TargetMol
SKU: T26859
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26859Cas No. 1675201-90-7

BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.

BMS-8

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Purity: 98.88%

Catalog No. T26859Cas No. 1675201-90-7

BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$76	In Stock
10 mg	$133	In Stock
25 mg	$247	In Stock
50 mg	$378	In Stock
100 mg	$562	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock

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Batch Information

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Purity:98.88%

Resource Download

COA HNMR LCMS HPLC

Product Introduction

Bioactivity

Description	BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.
Targets&IC50	PD-1/PD-L1:7.2 μM
In vitro	BMS-8 demonstrates a more stable binding affinity for one PD-L1 monomer compared to another, with its ability to induce PD-L1 dimerization further enhanced by non-polar interactions involving Ile54, Tyr56, Met115, Ala121, and Tyr123 on each monomer, in addition to the involvement of water-mediated bridges at ALys124[2].

Chemical Properties

Molecular Weight	494.42
Formula	C₂₇H₂₈BrNO₃
Cas No.	1675201-90-7
Smiles	Cc1c(COc2ccc(CN3CCCCC3C(O)=O)cc2Br)cccc1-c1ccccc1
Relative Density.	1.334 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (121.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0226 mL	10.1129 mL	20.2257 mL	101.1286 mL
5 mM	0.4045 mL	2.0226 mL	4.0451 mL	20.2257 mL
10 mM	0.2023 mL	1.0113 mL	2.0226 mL	10.1129 mL
20 mM	0.1011 mL	0.5056 mL	1.0113 mL	5.0564 mL
50 mM	0.0405 mL	0.2023 mL	0.4045 mL	2.0226 mL
100 mM	0.0202 mL	0.1011 mL	0.2023 mL	1.0113 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc