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Anti-LAIR1 Monoclonal Antibody-Biotin (Synonyms: Leukocyte-associated immunoglobulin-like receptor 1)

Catalog No. TMAZ-0197B Copy Product Info
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Anti-LAIR1 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LAIR1. Anti-LAIR1 Monoclonal Antibody-Biotin can be used in ELISA,FCM.

Anti-LAIR1 Monoclonal Antibody-Biotin

Copy Product Info
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Catalog No. TMAZ-0197B
Synonyms Leukocyte-associated immunoglobulin-like receptor 1

Anti-LAIR1 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LAIR1. Anti-LAIR1 Monoclonal Antibody-Biotin can be used in ELISA,FCM.

Anti-LAIR1 Monoclonal Antibody-Biotin
Pack SizePriceUSA StockGlobal StockQuantity
25 μg$16312 days12 days
50 μg$19612 days12 days
100 μg$27412 days12 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-LAIR1 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LAIR1. Anti-LAIR1 Monoclonal Antibody-Biotin can be used in ELISA,FCM.
SynonymsLeukocyte-associated immunoglobulin-like receptor 1
Ig Type
Rabbit monoclonal IgG
Reactivity
Human
Verified Activity
Flow cytometry analysis of LAIR1 overexpressed 293F cells with TMAZ-0197BBI, which was counjucated with SA-PE (red). The WT 293F control is black line.
Application
ELISA
FCM
Recommended Dose
0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationSingle-pass type I membrane
ConstructionThis antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of LAIR1 protein.
PurificationProtein A Affinity Purified
AppearanceLiquid
Formulation0.22 μm filtered solution in PBS.
Purity> 95% as determined by SDS-PAGE.
Research BackgroundFunctions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells
Related Conjugates and Formulations
Conjucates
Biotin
Others Formats
Unconjugated
Antibody Types Available
2
Antigen Details
Immunogen
LAIR1
Antigen Species
Human
Gene ID
3903
Uniprot ID
Q6GTX8
Biology Area
Drug Target
Chemical Properties
Molecular Weight150 kDa
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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