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Anti-ApoER2 Polyclonal Antibody
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Catalog No. TMAB-00131
Alias LRP-8, LRP8, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, APOER2
Anti-ApoER2 Polyclonal Antibody is a Rabbit antibody targeting ApoER2. Anti-ApoER2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Anti-ApoER2 Polyclonal Antibody
Anti-ApoER2 Polyclonal Antibody
😃Good
Catalog No. TMAB-00131Alias LRP-8, LRP8, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, APOER2
Anti-ApoER2 Polyclonal Antibody is a Rabbit antibody targeting ApoER2. Anti-ApoER2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $528 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ApoER2 Polyclonal Antibody is a Rabbit antibody targeting ApoER2. Anti-ApoER2 Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF. |
| Alias | LRP-8, LRP8, Low-density lipoprotein receptor-related protein 8, Apolipoprotein E receptor 2, APOER2 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | 1. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Incubation: Anti-ApoER2 Polyclonal Antibody, Unconjugated (TMAB-00131) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining. 2. Sample: Lane 1: Lung (Mouse) Lysate at 40 μg Lane 2: Lung (Rat) Lysate at 40 μg Lane 3: U87MG (Human) Lysate at 40 μg Lane 4: Hela (Human) Lysate at 40 μg Primary: Anti-ApoER2 (TMAB-00131) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 170/130 kDa Observed band size: 130/125 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane. Secreted. Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Research Background | Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. |
| Immunogen | KLH conjugated synthetic peptide: human ApoER2 |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Apolipoproteins,Cancer,Obesity,Neurodegenerative disease,Neurogenesis,Lipid metabolism |
| Molecular Weight | Theoretical: 102 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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